Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680825 | 0.89 | MAPT (0.41) | RARARARBSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13680835 | 0.87 | MAP4K4 (0.42) | RAB9ANPC1MAPK8PIK3CGGSK3B | |
| SCHEMBL3854280 | 0.85 | MEN1 (0.50) | RAB9AALDH1A1PDE10A | |
| SCHEMBL13680828 | 0.84 | ALDH1A1 (0.42) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13680836 | 0.84 | NPC1 (0.44) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13680837 | 0.84 | ALDH1A1 (0.40) | KDM4EALDH1A1TP53 | |
| SCHEMBL13680834 | 0.81 | PDE10A (0.39) | RAB9ASMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL13680827 | 0.80 | KMT2A (0.50) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13680840 | 0.80 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL6200651 | 0.79 | RAB9A (0.51) | RARARARBCHEK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |