Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 5/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680825 | 0.87 | MAPT (0.41) | MAPTSMN1; SMN2ATRTRPV3ADORA3 | |
| SCHEMBL13680828 | 0.85 | ALDH1A1 (0.42) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13680830 | 0.84 | RARA (0.44) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13680835 | 0.83 | MAP4K4 (0.42) | NPC1RAB9AMKNK2MKNK1 | |
| SCHEMBL13680837 | 0.82 | ALDH1A1 (0.40) | ATRHDAC4 | |
| SCHEMBL13680839 | 0.81 | ALDH1A1 (0.45) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13680827 | 0.81 | KMT2A (0.50) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13680834 | 0.79 | PDE10A (0.39) | MAPTRAB9ASMN1; SMN2TRPV3ADORA3 | |
| SCHEMBL13680840 | 0.78 | RAB9A (0.41) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13680844 | 0.78 | SMN1; SMN2 (0.43) | NPC1MAPTRAB9ASMN1; SMN2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |