Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.52 |
| ▸ | MMP1 | P03956 | 10/20 | 0.52 |
| ▸ | MMP2 | P08253 | 9/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.47 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MMP16 | P51512 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899011 | 0.85 | LMNA (0.47) | MMP13MMP1MMP2MMP9BMP1 | |
| SCHEMBL3921655 | 0.84 | MMP2 (0.47) | MMP13MMP1MMP2MMP9BMP1 | |
| SCHEMBL13898952 | 0.82 | RORC (0.47) | MMP13MMP1MMP2MMP9BMP1 | |
| SCHEMBL13898736 | 0.80 | BMP1 (0.48) | MMP13MMP1MMP2MMP9BMP1 | |
| SCHEMBL8456469 | 0.79 | MMP9 (0.50) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL13899083 | 0.78 | MMP2 (0.67) | MMP13MMP1MMP2MMP9PTGES | |
| SCHEMBL14507726 | 0.77 | MMP13 (0.61) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL6817940 | 0.75 | MMP1 (0.48) | MMP13MMP1MMP2MMP9NR3C1 | |
| SCHEMBL231737 | 0.75 | MMP1 (0.55) | MMP13MMP1MMP2MMP9NR3C1 | |
| SCHEMBL3922892 | 0.73 | MMP1 (0.61) | MMP13MMP1MMP2MMP9PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |