Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 8/20 | 0.48 |
| ▸ | CTSL | P07711 | 6/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541279 | 0.76 | ALDH1A1 (0.52) | IDO1TDO2CTSKCTSLCTSS | |
| SCHEMBL8769884 | 0.75 | CTRB1 (0.57) | IDO1TDO2CTSKCTSLCTSS | |
| SCHEMBL7082474 | 0.75 | CTSK (0.51) | IDO1TDO2ATMCTSKCTSL | |
| SCHEMBL22698689 | 0.75 | ATM (0.56) | ATMCTSKCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21248689 | 0.74 | ATM (0.52) | ATMCTSKCTSLCTSSCTSB | |
| SCHEMBL308291 | 0.74 | ATM (0.64) | ATMCTSKCTSLCTSSCTSB | |
| SCHEMBL8041576 | 0.74 | ATM (0.64) | ATMCTSKCTSLCTSSCTSB | |
| SCHEMBL7332929 | 0.73 | ATM (0.56) | ATMCTSKCTSLCTSSCTSB | |
| SCHEMBL7404857 | 0.73 | ATM (0.56) | ATMCTSKCTSLCTSSCTSB | |
| SCHEMBL7328376 | 0.72 | ALDH1A1 (0.62) | ATMCTSKCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482372-B2 | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-27 | — | — | US | disclosed |