SCHEMBL1401865

SCHEMBL1401865

C=CC(=O)OOc1cccc(CCC)c1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.54
ALOX5 P09917 1/20 0.44
ACHE P22303 3/20 0.43
PPARA Q07869 4/20 0.43
PPARG P37231 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1401869 0.87 THRB (0.67) THRBALOX5ACHEPPARAPPARG
SCHEMBL1401816 0.80 ALOX5 (0.44) ALOX5ACHEPPARAPPARG
SCHEMBL27204581 0.79 KDM4E (0.48) THRB
SCHEMBL28765752 0.77 CES2 (0.47)
SCHEMBL23392587 0.76 THRB (0.68) THRBPPARAPPARG
SCHEMBL2724431 0.76 THRB (0.68) THRBPPARAPPARG
SCHEMBL15995743 0.76 THRB (0.68) THRBPPARAPPARG
SCHEMBL28671331 0.75 THRB (0.45) THRBALOX5ACHEPPARAPPARG
SCHEMBL819501 0.74 THRB (0.53) THRBALOX5ACHE
SCHEMBL19456776 0.74 THRB (0.53) THRBACHEPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2018-12-06 US claimed
EP-2292672-B1 Biocompatible polymers and co-polymers comprising amino acids in the side chain CIS PHARMA AG (CH) 2018-05-09 EP claimed
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS (CH) 2017-06-01 US claimed
EP-1888660-B1 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CIS PHARMA AG (CH) 2017-05-17 EP claimed
US-8980957-B2 Methods for the preparation of biocompatible polymers, the polymers and their uses CIS PHARMA AG (CH) 2015-03-17 US claimed
US-20140242722-A1 ARTICLE AND METHOD FOR DETECTION OF A DRUG IN A LIQUID MEDIUM MEDTECH DETECT, LLC (US) 2014-08-28 US claimed
WO-2014062910-A1 SPIROPYRAN-BASED COLORIMETRIC DETECTION MEDTECH DETECT, LLC (US) 2014-04-24 WO claimed
US-20120329902-A1 METHODS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS, THE POLYMERS AND THEIR USES SCHAEFER ROLF (CH) 2012-12-27 US claimed
EP-2523982-A1 METHODS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS, THE POLYMERS AND THEIR USES Chemisches Institut Schaefer AG (CH) 2012-11-21 EP claimed
WO-2011085988-A1 METHODS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS, THE POLYMERS AND THEIR USES CHEMISCHES INSTITUT SCHAEFER AG (CH) 2011-07-21 WO claimed
EP-2292672-A2 Biocompatible polymers and co-polymers comprising amino acids in the side chain Chemisches Institut Schaefer AG (CH) 2011-03-09 EP claimed
US-20090232871-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS 2009-09-17 US claimed
EP-1888660-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN Chemisches Institut Schaefer AG (CH) 2008-02-20 EP claimed
WO-2006126095-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CHEMISCHES INSTITUT SCHAEFER AG (CH) 2006-11-30 WO claimed
US-11008414-B2 Polymer materials for contact lens applications CIS PHARMA AG (CH) 2021-05-18 US disclosed
US-20200283560-A1 New polymer materials for contact lens applications CIS PHARMA AG (CH) 2020-09-10 US disclosed
EP-3356433-B1 NEW POLYMER MATERIALS FOR CONTACT LENS APPLICATIONS CIS PHARMA AG (CH) 2019-09-18 EP disclosed
US-20090232871-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS 2009-09-17 US disclosed
EP-1888660-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN Chemisches Institut Schaefer AG (CH) 2008-02-20 EP disclosed
WO-2006126095-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CHEMISCHES INSTITUT SCHAEFER AG (CH) 2006-11-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090232871-A1 Biocompatible polymers and co-polymers, and uses thereof PPIH, ARG1, P4HA1 THRB 3915/4885ALOX5 310/4885ACHE 2016/4885
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 THRB 4338/4885ALOX5 1377/4885ACHE 839/4885
US-20200283560-A1 New polymer materials for contact lens applications CRYAA, CRYAB, BCAT1 THRB 2348/4885ALOX5 1381/4885ACHE 4378/4885
US-11008414-B2 Polymer materials for contact lens applications CRYAA, BCAT1, CRYAB THRB 2290/4885ALOX5 1462/4885ACHE 4229/4885
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 THRB 4338/4885ALOX5 1377/4885ACHE 839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.