Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12722433 | 0.84 | CTSB (0.53) | EGLN1BCHEMAPTALDH1A1MEN1 | |
| SCHEMBL11955296 | 0.82 | BCHE (0.48) | EGLN1BCHEMAPTALDH1A1MEN1 | |
| SCHEMBL4037379 | 0.82 | L3MBTL1 (0.61) | EGLN1BCHEALDH1A1KMT2AHTT | |
| SCHEMBL9310765 | 0.81 | ALDH1A1 (0.56) | EGLN1BCHEMAPTALDH1A1KMT2A | |
| SCHEMBL6912855 | 0.80 | HTR5A (0.54) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1714944 | 0.79 | BCHE (0.49) | EGLN1BCHEMAPTALDH1A1MEN1 | |
| SCHEMBL17223780 | 0.79 | BCHE (0.48) | EGLN1BCHEMAPTALDH1A1MEN1 | |
| SCHEMBL11967425 | 0.79 | TERT (0.52) | EGLN1BCHEMAPTALDH1A1MEN1 | |
| SCHEMBL2359289 | 0.78 | LMNA (0.52) | EGLN1BCHEMAPTALDH1A1HTT | |
| SCHEMBL11770828 | 0.78 | EGLN1 (0.49) | EGLN1BCHEALDH1A1HSP90AA1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044107-A1 | Inhibitors of JMJD2C as Anticancer Agents | THE J. DAVID GLADSTONE INSTITUTES | 2017-02-16 | — | — | US | disclosed |
| US-9233995-B2 | Quinazoline derivatives and quinazoline complex protein kinase inhibitor for inhibiting multiplication of tumor cells and preparation method thereof | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-01-12 | — | — | US | disclosed |
| US-8562922-B2 | Picolylamine resins | LANXESS DEUTSCHLAND GMBH (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2259874-B1 | PICOLYLAMINE RESINS | LANXESS DEUTSCHLAND GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20130225811-A1 | QUINAZOLINE DERIVATIVES AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICAITON OF TUMOR CELLS AND PREPARATION METHOD THEREOF | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCE (CN) | 2013-08-29 | — | — | US | disclosed |
| WO-2007101584-A2 | RADIONUCLIDE RESINS | LANXESS DEUTSCHLAND GMBH (DE) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007088010-A1 | MONODISPERSE, MACROPOROUS CHELATING RESINS IN METAL WINNING | LANXESS DEUTSCHLAND GMBH (DE) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044107-A1 | Inhibitors of JMJD2C as Anticancer Agents | KDM2A, KDM1B, KDM5C | EGLN1 170/4885BCHE 3780/4885MAPT 3264/4885 |
| US-20130225811-A1 | QUINAZOLINE DERIVATIVES AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICAITON OF TUMOR CELLS AND PREPARATION METHOD THEREOF | MAP3K21, MAP3K15, MAP3K14 | EGLN1 4222/4885BCHE 3277/4885MAPT 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.