Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUMO2 | P61956 | 2/20 | 1.00 |
| ▸ | SUMO1 | P63165 | 2/20 | 1.00 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 1.00 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 1.00 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 1.00 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 1.00 |
| ▸ | ENPP2 | Q13822 | 9/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374866 | 1.00 | SUMO2 (1.00) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL4952032 | 0.93 | SUMO2 (0.86) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL14413371 | 0.93 | SUMO2 (0.86) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL29637786 | 0.92 | SUMO2 (0.84) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL14418340 | 0.91 | SUMO2 (0.83) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL19132261 | 0.88 | SENP2 (0.78) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL9793656 | 0.87 | SUMO2 (0.77) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL7804546 | 0.87 | ENPP2 (1.00) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL14418367 | 0.87 | ENPP2 (1.00) | SUMO2SUMO1SENP7SENP2SENP3 | |
| SCHEMBL14613567 | 0.85 | SUMO2 (0.74) | SUMO2SUMO1SENP7SENP2SENP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11041859-B2 | Methods of identifying SENP1 inhibitors | CITY OF HOPE (US) | 2021-06-22 | — | — | US | disclosed |
| US-20180143196-A1 | METHODS OF IDENTIFYING SENP1 INHIBITORS | CITY OF HOPE | 2018-05-24 | — | — | US | disclosed |
| US-20180143196-A1 | METHODS OF IDENTIFYING SENP1 INHIBITORS | CITY OF HOPE | 2018-05-24 | — | — | US | disclosed |
| US-9791447-B2 | Methods of identifying SENP1 inhibitors | CITY OF HOPE (US) | 2017-10-17 | — | — | US | disclosed |
| US-9791447-B2 | Methods of identifying SENP1 inhibitors | CITY OF HOPE (US) | 2017-10-17 | — | — | US | disclosed |
| US-20140302525-A1 | METHODS OF IDENTIFYING SENP1 INHIBITORS | CITY OF HOPE (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140302525-A1 | METHODS OF IDENTIFYING SENP1 INHIBITORS | CITY OF HOPE (US) | 2014-10-09 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | AMBION, INC (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | RNASE1, RNASEH1, RNASEL | SUMO2 3330/4885SUMO1 3284/4885SENP7 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.