Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 10/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.56 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 0.56 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.56 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CD40 | P25942 | 1/20 | 0.48 |
| ▸ | CD40LG | P29965 | 1/20 | 0.48 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14608472 | 0.89 | KMT2A (0.77) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL14418373 | 0.88 | ENPP2 (0.67) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL10622991 | 0.86 | HIF1A (0.98) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL6846279 | 0.85 | HIF1A (1.00) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL8816124 | 0.85 | HIF1A (1.00) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL4068193 | 0.85 | HIF1A (1.00) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL592666 | 0.85 | HIF1A (0.69) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL4579446 | 0.84 | HIF1A (0.78) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL28661864 | 0.83 | THRB (0.67) | ALDH1A1HIF1AMEN1KMT2ATHRB | |
| SCHEMBL1598797 | 0.83 | THRB (0.67) | ALDH1A1HIF1AMEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131243-A1 | METHODS OF ATTENUATING AN IMMUNE RESPONSE BY INHIBITION OF BFL1 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230131243-A1 | METHODS OF ATTENUATING AN IMMUNE RESPONSE BY INHIBITION OF BFL1 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-04-27 | — | — | US | disclosed |
| US-11541073-B2 | Methods of attenuating an immune response by inhibition of BFL1 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210113604-A1 | METHODS OF TREATMENT BY INHIBITION OF BFL1 | CHILDREN'S HOSPITAL MEDICAL CENTER | 2021-04-22 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | AMBION, INC (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | RNASE1, RNASEH1, RNASEL | ALDH1A1 2603/4885HIF1A 1080/4885MEN1 2073/4885 |
| US-20230131243-A1 | METHODS OF ATTENUATING AN IMMUNE RESPONSE BY INHIBITION OF BFL1 | CD74, IRF3, IRF2BP2 | ALDH1A1 4322/4885HIF1A 507/4885MEN1 4808/4885 |
| US-20210113604-A1 | METHODS OF TREATMENT BY INHIBITION OF BFL1 | DNASE1L3, ILF2, NCF1 | ALDH1A1 4123/4885HIF1A 503/4885MEN1 4786/4885 |
| US-11541073-B2 | Methods of attenuating an immune response by inhibition of BFL1 | CD74, IRF3, IRF2BP2 | ALDH1A1 4322/4885HIF1A 507/4885MEN1 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.