SCHEMBL145336

SCHEMBL145336

NC(=S)Nc1cc(F)ccc1F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.49
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
ALDH1A1 P00352 4/20 0.49
HTT P42858 2/20 0.49
LMNA P02545 1/20 0.49
MAPT P10636 3/20 0.44
POLB P06746 1/20 0.44
PKM P14618 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.41
TSHR P16473 1/20 0.41
KDM4E B2RXH2 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX12 P18054 1/20 0.41
CYP2C19 P33261 1/20 0.41
CA3 P07451 1/20 0.40
CA6 P23280 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30542253 1.00 SMN1; SMN2 (0.49) SMN1; SMN2MEN1KMT2AALDH1A1HTT
SCHEMBL29639366 0.84 LMNA (0.53) SMN1; SMN2KMT2AALDH1A1HTTLMNA
SCHEMBL140667 0.84 LMNA (0.53) SMN1; SMN2KMT2AALDH1A1HTTLMNA
SCHEMBL6835277 0.81 ALDH1A1 (0.51) MEN1KMT2AALDH1A1HTTLMNA
SCHEMBL4196937 0.81 IDO1 (0.46) SMN1; SMN2MEN1KMT2AALDH1A1HTT
SCHEMBL23120403 0.81 L3MBTL1 (0.39) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL23496839 0.81 L3MBTL1 (0.56) SMN1; SMN2MEN1KMT2AALDH1A1HTT
SCHEMBL29876645 0.81 L3MBTL1 (0.56) SMN1; SMN2MEN1KMT2AALDH1A1HTT
SCHEMBL15689160 0.80 SMN1; SMN2 (0.49) SMN1; SMN2MEN1KMT2AALDH1A1HTT
SCHEMBL5154487 0.80 SMN1; SMN2 (0.55) SMN1; SMN2MEN1KMT2AALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113493219-A Tin dioxide quantum dot material, preparation method thereof and photoelectric device 香港理工大学深圳研究院 2021-10-12 CN claimed
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING PARIS SCIENCES ET LETTRES (FR) 2025-02-13 US disclosed
EP-4444308-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING Institut Curie (FR) 2024-10-16 EP disclosed
US-20230263167-A1 METHOD OF PREPARING A BISMUTH SULFIDE PARTICLE CONTAINING ANTIBACTERIAL COMPOSITION IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2023-08-24 US disclosed
US-11700855-B2 Method for preventing or reducing growth of a microorganism on a surface IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2023-07-18 US disclosed
WO-2023104976-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING INSTITUT CURIE (FR) 2023-06-15 WO disclosed
CN-113493219-A Tin dioxide quantum dot material, preparation method thereof and photoelectric device 香港理工大学深圳研究院 2021-10-12 CN disclosed
US-20210061670-A1 METHOD FOR PREVENTING OR REDUCING GROWTH OF A MICROORGANISM ON A SURFACE IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2021-03-04 US disclosed
US-10934176-B2 Methods of degrading organic pollutants and preventing or treating microbe using Bi2S3-CdS particles IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2021-03-02 US disclosed
US-20200102228-A1 METHODS OF DEGRADING ORGANIC POLLUTANTS AND PREVENTING OR TREATING MICROBE USING Bi2S3-CdS PARTICLES IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2020-04-02 US disclosed
US-9346686-B2 Copper-containing nanocrystals and methods of preparation therefor THE UNIVERSITY OF WESTERN ONTARIO (CA) 2016-05-24 US disclosed
US-20150360967-A1 COPPER-CONTAINING NANOCRYSTALS AND METHODS OF PREPARATION THEREFOR THE UNIVERSITY OF WESTERN ONTARIO (CA) 2015-12-17 US disclosed
CN-104136375-A COPPER-CONTAINING NANOCRYSTALS AND METHODS OF PREPARATION THEREFOR UNIV WESTERN ONTARIO 2014-11-05 CN disclosed
WO-2013091114-A1 COPPER-CONTAINING NANOCRYSTALS AND METHODS OF PREPARATION THEREFOR THE UNIVERSITY OF WESTERN ONTARIO (CA) 2013-06-27 WO disclosed
US-20120059163-A1 Non-linear opticaly active molecules, their synthesis, and use OPTIMER PHOTONICS, INC. (US) 2012-03-08 US disclosed
US-20090286813-A1 Thioxanthine Derivatives and Their Use as Inhibitors of MPO ASTRAZENECA AB (SE) 2009-11-19 US disclosed
EP-2010534-A1 THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO AstraZeneca AB (SE) 2009-01-07 EP disclosed
US-20080004415-A1 Non-linear optically active molecules, their synthesis, and use OPTIMER PHOTONICS, INC. (US) 2008-01-03 US disclosed
WO-2007120097-A1 THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO ASTRAZENECA AB (SE) 2007-10-25 WO disclosed
US-20070040151-A1 Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems HERAEUS KULZER GMBH (DE) 2007-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286813-A1 Thioxanthine Derivatives and Their Use as Inhibitors of MPO MPO, XDH, EPX SMN1; SMN2 1754/4885MEN1 2777/4885KMT2A 2979/4885
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING STAT1, IFNG, IRF2BP2 SMN1; SMN2 3664/4885MEN1 3227/4885KMT2A 2840/4885
US-20120059163-A1 Non-linear opticaly active molecules, their synthesis, and use INCENP, CYBA, ADCY5 SMN1; SMN2 4522/4885MEN1 4480/4885KMT2A 3041/4885
US-20080004415-A1 Non-linear optically active molecules, their synthesis, and use INCENP, CYBA, PAICS SMN1; SMN2 4430/4885MEN1 4473/4885KMT2A 2961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.