Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29723099 | 1.00 | LMNA (0.39) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL29612243 | 0.98 | LMNA (0.38) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL29612249 | 0.98 | LMNA (0.38) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL1156717 | 0.98 | LMNA (0.38) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL27317473 | 0.87 | GABRA1 (0.42) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL2738303 | 0.83 | LMNA (0.38) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL13202844 | 0.83 | LMNA (0.38) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL7877780 | 0.82 | CYP3A4 (0.40) | LMNAGPR55CYP3A4HTT | |
| SCHEMBL12061470 | 0.81 | PDE2A (0.40) | LMNATRPA1SLC6A2HTR2BCHRM1 | |
| SCHEMBL12061474 | 0.81 | CYP3A4 (0.52) | LMNASLC6A2HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018158674-A1 | ASYMMETRIC SYNTHESIS OF (S)-3-(1-(DIMETHYLAMINO) ETHYL) PHENYLETHYL(METHYL)CARBAMATE AND ITS SALTS | TROY LIFE SCIENCES (IN) | 2018-09-07 | — | — | WO | claimed |
| US-8921561-B2 | One-pot preparation of hexahydroisoquinolines from amides | MALLINCKRODT LLC (US) | 2014-12-30 | — | — | US | claimed |
| US-20130137874-A1 | One-Pot Preparation of Hexahydroisoquinolines from Amides | MALLINCKRODT LLC (US) | 2013-05-30 | — | — | US | claimed |
| US-8431705-B2 | One-pot preparation of hexahydroisoquinolines from amides | MALLINCKRODT LLC (US) | 2013-04-30 | — | — | US | claimed |
| WO-2012096824-A1 | PHENYLGLYOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | TRANSTECH PHARMA, INC. (US) | 2012-07-19 | — | — | WO | claimed |
| WO-2011038172-A1 | ONE-POT PREPARATION OF HEXAHYDROISOQUINOLINES FROM DIHYDROISOQUINOLINES | MALLINCKRODT INC. (US) | 2011-03-31 | — | — | WO | claimed |
| WO-2011038169-A2 | ONE-POT PREPARATION OF HEXAHYDROISOQUINOLINES FROM AMIDES | MALLINCKRODT INC. (US) | 2011-03-31 | — | — | WO | claimed |
| US-20110071299-A1 | One-Pot Preparation of Hexahydroisoquinolines from Amides | MALLINCKRODT INC. (US) | 2011-03-24 | — | — | US | claimed |
| US-20110071300-A1 | One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines | MALLINCKRODT INC. (US) | 2011-03-24 | — | — | US | claimed |
| US-20240059710-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-02-22 | — | — | US | disclosed |
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20230081426-A1 | COMPOUNDS AND METHODS FOR KRAS MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2023-03-16 | — | — | US | disclosed |
| US-20230002364-A1 | BENZOTHIOPHENE DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
| WO-2018158674-A1 | ASYMMETRIC SYNTHESIS OF (S)-3-(1-(DIMETHYLAMINO) ETHYL) PHENYLETHYL(METHYL)CARBAMATE AND ITS SALTS | TROY LIFE SCIENCES (IN) | 2018-09-07 | — | — | WO | disclosed |
| EP-1734034-A2 | Carboxylic acid salts of beta-alanine esters or -amides | Warner-Lambert Company LLC (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-1728785-A1 | 7-[(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-heptanoic acid ester 3,5-dioxo-acetal | Warner-Lambert Company LLC (US) | 2006-12-06 | — | — | EP | disclosed |
| EP-1724256-A2 | Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide | Warner-Lambert Company LLC (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20050239869-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1eta-pyrrole-3-carboxylic acid phenylamide | BUTLER DONALD E | 2005-10-27 | — | — | US | disclosed |
| US-20020133026-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | BUTLER DONALD EUGENE (US) | 2002-09-19 | — | — | US | disclosed |
| EP-0257866-B1 | PROCESS FOR PRODUCING 2,5-DICHLOROTOLUENE | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240059710-A1 | KRAS G12D Inhibitors | KRAS, NRAS, HRAS | LMNA 3252/4885TRPA1 4830/4885SLC6A2 4876/4885 |
| US-20110071299-A1 | One-Pot Preparation of Hexahydroisoquinolines from Amides | QARS1, QTRT1, SFPQ | LMNA 3515/4885TRPA1 3964/4885SLC6A2 2058/4885 |
| US-20230081426-A1 | COMPOUNDS AND METHODS FOR KRAS MODULATION AND INDICATIONS THEREFOR | KRAS, NRAS, HRAS | LMNA 2429/4885TRPA1 3709/4885SLC6A2 2430/4885 |
| US-20050239869-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1eta-pyrrole-3-carboxylic acid phenylamide | PAH, PCCA, HPD | LMNA 2962/4885TRPA1 4023/4885SLC6A2 2404/4885 |
| US-20020133026-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | PCCA, PAH, HPD | LMNA 3504/4885TRPA1 4171/4885SLC6A2 3205/4885 |
| US-20130137874-A1 | One-Pot Preparation of Hexahydroisoquinolines from Amides | QARS1, QTRT1, SFPQ | LMNA 3515/4885TRPA1 3964/4885SLC6A2 2058/4885 |
| US-20230002364-A1 | BENZOTHIOPHENE DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | GPER1, GABRQ, GPR39 | LMNA 4444/4885TRPA1 535/4885SLC6A2 799/4885 |
| US-20110071300-A1 | One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines | QDPR, QTRT1, DHPS | LMNA 3491/4885TRPA1 3994/4885SLC6A2 1677/4885 |
| US-20240025918-A1 | KRAS G12D Inhibitors | KRAS, NRAS, HRAS | LMNA 2462/4885TRPA1 4074/4885SLC6A2 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.