SCHEMBL14633779

SCHEMBL14633779

CC(C)(C)OC(=O)Nc1cccc(CCl)[n+]1[O-]

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.36
LCK P06239 3/20 0.35
CYP17A1 P05093 1/20 0.34
ATR Q13535 1/20 0.34
CA1 P00915 5/20 0.34
CA12 O43570 3/20 0.34
CA7 P43166 1/20 0.34
CA14 Q9ULX7 1/20 0.34
CA2 P00918 4/20 0.34
CA9 Q16790 2/20 0.33
RXFP1 Q9HBX9 1/20 0.33
NAMPT P43490 1/20 0.33
DRD2 P14416 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
EPHX2 P34913 1/20 0.33
AKT1 P31749 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14634232 0.80 LCK (0.39) LCKCYP17A1ATRCA1CA12
SCHEMBL823328 0.73 LMNA (0.39) ATMCYP17A1ATRCA1CA12
SCHEMBL14633891 0.70 NLRP3 (0.42)
SCHEMBL8307596 0.69 CCR2 (0.44) LCKCYP17A1ATR
SCHEMBL7911540 0.68 AURKA (0.49) CYP17A1CA1CA12CA2CA9
SCHEMBL17220667 0.67 LMNA (0.48) CYP17A1CA1CA12CA7CA14
SCHEMBL7997538 0.67 ALDH1A1 (0.47) LCKRXFP1
SCHEMBL14633780 0.67 CA12 (0.35) CA1CA12CA14CA2CA9
SCHEMBL17230175 0.67 ALDH1A1 (0.47) ATMLCKRXFP1DRD2
SCHEMBL13199871 0.67 KDM4A (0.47) ATMCA1CA12CA7CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2842944-B1 METHOD FOR PRODUCING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND NIPPON SODA CO (JP) 2017-03-15 EP disclosed
EP-2557078-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO (JP) 2016-03-23 EP disclosed
EP-2730561-B1 Methods to prepare haloalkyl nitrogen-containing heterocyclic compounds NIPPON SODA CO (JP) 2015-10-14 EP disclosed
US-8981107-B2 Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO., LTD. (JP) 2015-03-17 US disclosed
EP-2842944-A1 Method for producing nitrogen-containing heterocyclic compound NIPPON SODA CO., LTD. (JP) 2015-03-04 EP disclosed
US-8962850-B2 Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO., LTD. (JP) 2015-02-24 US disclosed
US-8962849-B2 Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO., LTD. (JP) 2015-02-24 US disclosed
US-8809544-B2 Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO., LTD. (JP) 2014-08-19 US disclosed
US-20140194629-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2014-07-10 US disclosed
CN-102844302-B Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO 2014-07-09 CN disclosed
US-20140171651-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2014-06-19 US disclosed
US-20140163235-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2014-06-12 US disclosed
US-20140155616-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2014-06-05 US disclosed
EP-2730561-A1 Methods to prepare nitrogen-containing heterocyclic compounds NIPPON SODA CO., LTD. (JP) 2014-05-14 EP disclosed
US-8703959-B2 Nitrogen-containing heterocyclic compound and method for producing same NIPPON SODA CO., LTD (JP) 2014-04-22 US disclosed
EP-2557078-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME Nippon Soda Co., Ltd. (JP) 2013-02-13 EP disclosed
US-20130023664-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2013-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140163235-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NOS1, NOS2, NOS3 ATM 888/4885LCK 2739/4885CYP17A1 587/4885
US-20140171651-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NOS1, NOS2, NOS3 ATM 888/4885LCK 2739/4885CYP17A1 587/4885
US-20130023664-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NOS1, NOS2, NOS3 ATM 888/4885LCK 2739/4885CYP17A1 587/4885
US-20140155616-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NOS1, NOS2, NOS3 ATM 888/4885LCK 2739/4885CYP17A1 587/4885
US-20140194629-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME NOS1, NOS2, NOS3 ATM 888/4885LCK 2739/4885CYP17A1 587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.