Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.35 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536999 | 0.86 | TRPV1 (0.45) | L3MBTL1KDM4ENPSR1PTGS1TRPV1 | |
| SCHEMBL5743149 | 0.80 | LMNA (0.44) | ATMCYP1A2CYP2C19L3MBTL1CACNA1C | |
| SCHEMBL2528015 | 0.79 | FABP4 (0.45) | ATMCYP1A2CYP2C19POLBCYP3A4 | |
| SCHEMBL14668356 | 0.76 | AOC1 (0.41) | AOC1AOC3CACNA1CSCN5AKDM4E | |
| SCHEMBL14797674 | 0.74 | KDM4E (0.43) | ATMCYP1A2CYP2C19L3MBTL1POLB | |
| SCHEMBL2870247 | 0.74 | KDM4E (0.39) | CYP2C19CYP3A4CYP2C9LMNAKDM4E | |
| SCHEMBL15635649 | 0.72 | TAS2R14 (0.42) | CYP2C19LMNAKDM4EP2RX7GAA | |
| SCHEMBL5745561 | 0.72 | PGK1 (0.47) | CYP1A2CYP2C19L3MBTL1CYP3A4LMNA | |
| SCHEMBL2528587 | 0.72 | TRPV1 (0.45) | AOC1AOC3KDM4EPTGS1TRPV1 | |
| SCHEMBL16647839 | 0.71 | MAT2A (0.42) | CACNA1CSCN5APTGS1TRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3130589-A1 | HETEROCYCLIC AZA COMPOUNDS | Grünenthal GmbH (DE) | 2017-02-15 | — | — | EP | disclosed |
| EP-2760836-A1 | AMINE SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2014-08-06 | — | — | EP | disclosed |
| CN-103917523-A | Amine-substituted methanesulfonamide derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH | 2014-07-09 | — | — | CN | disclosed |
| US-8765733-B2 | Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| US-8765733-B2 | Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2014-07-01 | — | — | US | disclosed |
| EP-2736882-A1 | SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES | Grünenthal GmbH (DE) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013045451-A1 | AMINE SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045451-A1 | AMINE SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-04-04 | — | — | WO | disclosed |
| US-20130079320-A1 | Amine Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130079320-A1 | Amine Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| WO-2013013817-A1 | SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
| US-20130029961-A1 | Substituted Heterocyclic Aza Compounds | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
| WO-2013013817-A1 | SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES | Grünenthal GmbH (DE) | 2013-01-31 | — | — | WO | disclosed |
| US-20130029961-A1 | Substituted Heterocyclic Aza Compounds | GRUENENTHAL GMBH (DE) | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079320-A1 | Amine Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | TRPV1, TRPA1, TRPV3 | AOC1 3948/4885AOC3 3598/4885ATM 1114/4885 |
| US-20130029961-A1 | Substituted Heterocyclic Aza Compounds | TRPV1, GPR17, TRPV2 | AOC1 1423/4885AOC3 2727/4885ATM 4438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.