Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742913 | 0.89 | RAB9A (0.49) | KDM4EMAPK1HSD17B10KCNMA1ALDH1A1 | |
| SCHEMBL14743993 | 0.88 | MAPK1 (0.56) | LMNAKDM4EMAPK1KCNMA1SMN1; SMN2 | |
| SCHEMBL14743672 | 0.87 | KCNMA1 (0.50) | LMNAKDM4EMAPK1KCNMA1SMN1; SMN2 | |
| SCHEMBL14744244 | 0.84 | MAPK8 (0.49) | MAPK10ALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL14744022 | 0.82 | MAPT (0.39) | LMNASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL14743986 | 0.81 | L3MBTL1 (0.42) | LMNAKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL14744278 | 0.81 | ALDH1A1 (0.57) | KDM4ESMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL14743640 | 0.81 | KDM4E (0.43) | LMNAKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14743299 | 0.79 | ALDH1A1 (0.42) | LMNAKDM4EHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL14743883 | 0.78 | MAPK1 (0.46) | LMNAKDM4EMAPK1HSD17B10MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |