SCHEMBL14842133

SCHEMBL14842133

CCCC(NO)C(=O)NC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.65

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ SLC29A1 Q99808 1/20 0.58
▸ ADORA1 P30542 1/20 0.56
▸ ADORA2A P29274 1/20 0.55
▸ ADORA2B P29275 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6765504 0.86 KDM4E (0.48) ADORA1ADORA2AADORA2B
SCHEMBL453954 0.84 ADORA2A (0.57) ADORA2AADORA2B
SCHEMBL453952 0.84 ADORA2A (0.57) ADORA2AADORA2B
SCHEMBL29421357 0.84 ADORA2A (0.57) ADORA2AADORA2B
SCHEMBL28630248 0.84 ADORA2A (0.57) ADORA2AADORA2B
SCHEMBL453953 0.84 ADORA2A (0.57) ADORA2AADORA2B
SCHEMBL28409183 0.83 SLC29A1 (0.67) SLC29A1ADORA2AADORA2B
SCHEMBL15158098 0.82 SLC29A1 (0.65) SLC29A1ADORA2AADORA2B
SCHEMBL3022531 0.82 BMPR1B (0.68) SLC29A1ADORA2AADORA2B
SCHEMBL15865951 0.82 BMPR1B (0.68) SLC29A1ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1447 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240366793-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO CALIFORNIA INST OF TECHN (US) 2024-11-07 — — US claimed
US-20240229075-A1 IMPROVED NUCLEIC ACID SEQUENCE FOR CELL TYPE SPECIFIC EXPRESSION CureVac SE (DE) 2024-07-11 — — US claimed
WO-2024129779-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-06-20 — — WO claimed
EP-4379052-A2 MRNA PURIFICATION BY TANGENTIAL FLOW FILTRATION Ethris GmbH (DE) 2024-06-05 — — EP claimed
US-20240102065-A1 METHOD OF REDUCING THE IMMUNOSTIMULATORY PROPERTIES OF IN VITRO TRANSCRIBED RNA CureVac SE (DE) 2024-03-28 — — US claimed
EP-4334446-A1 IMPROVED NUCLEIC ACID SEQUENCE FOR CELL TYPE SPECIFIC EXPRESSION CureVac SE (DE) 2024-03-13 — — EP claimed
WO-2024031087-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION MODERNATX, INC. (US) 2024-02-08 — — WO claimed
EP-4306643-A2 PLASMID CONTAINING A SEQUENCE ENCODING AN MRNA WITH A SEGMENTED POLY(A) TAIL ethris GmbH (DE) 2024-01-17 — — EP claimed
WO-2023215498-A2 COMPOSITIONS AND METHODS FOR CD28 ANTAGONISM MODERNATX, INC. (US) 2023-11-09 — — WO claimed
EP-4087938-A2 METHOD OF REDUCING THE IMMUNOSTIMULATORY PROPERTIES OF IN VITRO TRANSCRIBED RNA CureVac AG (DE) 2022-11-16 — — EP claimed
US-20220296628-A1 RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES CUREVAC AG (DE) 2022-09-22 — — US claimed
WO-2022162027-A2 METHOD OF REDUCING THE IMMUNOSTIMULATORY PROPERTIES OF IN VITRO TRANSCRIBED RNA CUREVAC AG (DE) 2022-08-04 — — WO claimed
EP-4013880-A1 RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES CureVac AG (DE) 2022-06-22 — — EP claimed
WO-2021028439-A1 RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES CUREVAC AG (DE) 2021-02-18 — — WO claimed
EP-4746905-A1 RSV VACCINE Astrazeneca AB (SE) 2026-05-27 — — EP disclosed
US-12636304-B2 — — 2026-05-26 — — US disclosed
WO-2026104647-A1 VACCINE ASTRAZENECA AB (SE) 2026-05-21 — — WO disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 — — US disclosed
US-20130115272-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-09 — — US disclosed
WO-2013052523-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-04-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12636304-B2 — RNMT, RNGTT, NSUN2 SLC29A1 390/4885ADORA1 1426/4885ADORA2A 494/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 SLC29A1 41/4885ADORA1 161/4885ADORA2A 85/4885
US-20240229075-A1 IMPROVED NUCLEIC ACID SEQUENCE FOR CELL TYPE SPECIFIC EXPRESSION NSUN3, NSUN2, RNASE1 SLC29A1 413/4885ADORA1 2373/4885ADORA2A 1751/4885
US-20240102065-A1 METHOD OF REDUCING THE IMMUNOSTIMULATORY PROPERTIES OF IN VITRO TRANSCRIBED RNA RNGTT, POLRMT, POLR2H SLC29A1 1232/4885ADORA1 1427/4885ADORA2A 1134/4885
US-20220296628-A1 RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES TLR3, EIF2AK2, STING1 SLC29A1 3073/4885ADORA1 418/4885ADORA2A 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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