Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20117519 | 0.76 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL10100499 | 0.75 | KEAP1 (0.55) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL20032300 | 0.74 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL1490807 | 0.74 | ROCK2 (0.50) | ALDH1A1NR3C1 | |
| SCHEMBL698855 | 0.74 | KEAP1 (0.70) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL28012269 | 0.73 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KEAP1POLBMAPKAPK2 | |
| SCHEMBL1491018 | 0.73 | ADRB2 (0.42) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1490854 | 0.72 | L3MBTL1 (0.51) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4370199 | 0.72 | KEAP1 (0.52) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 | |
| SCHEMBL244843 | 0.72 | KEAP1 (0.52) | ALDH1A1SMN1; SMN2KEAP1POLBNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897609-B2 | Aryl substituted imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-03-01 | — | — | US | disclosed |