SCHEMBL1496782

SCHEMBL1496782

OC(CSc1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
KDM4E B2RXH2 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
AOC3 Q16853 4/20 0.45
RAB9A P51151 1/20 0.45
MTNR1A P48039 3/20 0.44
MTNR1B P49286 3/20 0.44
FFAR1 O14842 1/20 0.43
RIPK1 Q13546 1/20 0.42
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11603735 0.88 BACE1 (0.48) LMNAMAOAMAOBKDM4EL3MBTL1
SCHEMBL1496554 0.87 CHRNA7 (0.44) LMNAMAOAMAOBKDM4EL3MBTL1
SCHEMBL28820942 0.87 L3MBTL1 (0.50) LMNAMAOAMAOBKDM4EL3MBTL1
SCHEMBL1496598 0.84 ALDH1A1 (0.46) LMNAKDM4EL3MBTL1ALDH1A1RAB9A
SCHEMBL1496515 0.82 SMN1; SMN2 (0.46) LMNAKDM4EALDH1A1AOC3RAB9A
SCHEMBL6423185 0.79 LMNA (0.56) LMNAKDM4EL3MBTL1AOC3RAB9A
SCHEMBL4490473 0.79 LMNA (0.56) LMNAKDM4EL3MBTL1AOC3RAB9A
SCHEMBL916141 0.79 MAOA (0.56) MAOAMAOBALDH1A1MAPK1MTNR1A
SCHEMBL6693362 0.77 LMNA (0.60) LMNAKDM4EL3MBTL1AOC3RAB9A
SCHEMBL12727862 0.77 LMNA (0.60) LMNAKDM4EL3MBTL1AOC3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7906667-B2 Method for producing optically active alcohol compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-03-15 US disclosed
US-20100234629-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-16 US disclosed
US-7728179-B2 Method for producing optically active alcohol compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-01 US disclosed
EP-1380342-B1 COMPLEX CATALYST, PROCESS FOR PRODUCING THE COMPLEX CATALYST, AND PROCESS FOR PRODUCING ALCOHOL DERIVATIVE WITH THE COMPLEX CATALYST SUMITOMO CHEMICAL CO (JP) 2009-07-01 EP disclosed
US-20090012330-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-01-08 US disclosed
EP-1982972-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-10-22 EP disclosed
EP-1982973-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-10-22 EP disclosed
US-6995110-B2 Complex catalyst, process for producing the complex catalyst, and process for producing alcohol derivative with the complex catalyst SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-02-07 US disclosed
US-20040077487-A1 Complex catalyst, process for producing the complex catalyst, and process for producing alchohol derivative with the complex catalyst SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-04-22 US disclosed
EP-1380342-A1 COMPLEX CATALYST, PROCESS FOR PRODUCING THE COMPLEX CATALYST, AND PROCESS FOR PRODUCING ALCOHOL DERIVATIVE WITH THE COMPLEX CATALYST SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-01-14 EP disclosed
US-4267375-A REFLUXING THIOPHENOL IN BENZENE USING ZINC CHLORIDE AS CATALYST WITH PHENYL-/-OR 2- HYDROXYPHENETHYL SULFIDE S.A. TEXACO BELGIUM N.V. (BE) 1981-05-12 US disclosed
US-4267375-A REFLUXING THIOPHENOL IN BENZENE USING ZINC CHLORIDE AS CATALYST WITH PHENYL-/-OR 2- HYDROXYPHENETHYL SULFIDE S.A. TEXACO BELGIUM N.V. (BE) 1981-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012330-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND ADH1A, ADH1C, ADH5 LMNA 3411/4885MAOA 2068/4885MAOB 1978/4885
US-20100234629-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND ADH1A, ADH1C, ADH5 LMNA 3091/4885MAOA 2149/4885MAOB 2059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.