SCHEMBL15375397

SCHEMBL15375397

CCc1ccc(OCc2ccccc2C(O)C#N)c(CC)c1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 5/20 0.35
FOLH1 Q04609 1/20 0.35
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ABCB1 P08183 2/20 0.34
FFAR1 O14842 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
CD274 Q9NZQ7 3/20 0.34
ALDH1A1 P00352 3/20 0.34
FABP4 P15090 1/20 0.33
FABP5 Q01469 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
LMNA P02545 1/20 0.33
SGMS2 Q8NHU3 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15375308 0.90 MAPT (0.35) FFAR4FOLH1MAPTNPSR1L3MBTL1
SCHEMBL15375461 0.87 MAPT (0.46) MAPTNPSR1L3MBTL1CYP2C19ALDH1A1
SCHEMBL15375581 0.82 FFAR1 (0.41) FFAR4MAPTL3MBTL1FFAR1
SCHEMBL15375491 0.81 FABP4 (0.49) FFAR4FOLH1FFAR1CD274FABP4
SCHEMBL15375597 0.81 CYP2D6 (0.44) FFAR4FOLH1MAPTABCB1FFAR1
SCHEMBL15401894 0.80 ADRB2 (0.38) FFAR4FOLH1MAPTABCB1FFAR1
SCHEMBL15375368 0.79 FABP4 (0.40) MAPTNPSR1L3MBTL1FFAR1ALDH1A1
SCHEMBL15401683 0.79 OPRK1 (0.39) FFAR4FOLH1MAPTFFAR1ALDH1A1
SCHEMBL15375379 0.78 SGMS2 (0.38) FFAR4MAPTNPSR1FFAR1CYP2C19
SCHEMBL9667361 0.78 L3MBTL1 (0.42) FFAR4MAPTL3MBTL1FFAR1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2682382-B1 Method for Producing Phenylacetamide Compound SUMITOMO CHEMICAL CO (JP) 2016-11-23 EP disclosed
EP-2662352-B1 Method for Producing Phenylacetamide Compound SUMITOMO CHEMICAL CO (JP) 2016-11-09 EP disclosed
EP-2397459-B1 METHOD FOR PRODUCING PHENYLACETAMIDE COMPOUND SUMITOMO CHEMICAL CO (JP) 2015-12-16 EP disclosed
CN-103641731-B The manufacture method of phenylacetyl amine compound SUMITOMO CHEMICAL CO., LTD. (JP) 2015-10-28 CN disclosed
CN-103588657-A Method for producing phenylacetamide compound SUMITOMO CHEMICAL CO 2014-02-19 CN disclosed
EP-2682382-A2 Method for Producing Phenylacetamide Compound Sumitomo Chemical Company, Limited (JP) 2014-01-08 EP disclosed
US-8624062-B2 Method for producing phenylacetamide compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-07 US disclosed
EP-2662352-A2 Method for Producing Phenylacetamide Compound Sumitomo Chemical Company, Limited (JP) 2013-11-13 EP disclosed
EP-2397459-A1 METHOD FOR PRODUCING PHENYLACETAMIDE COMPOUND Sumitomo Chemical Company, Limited (JP) 2011-12-21 EP disclosed
US-20110295035-A1 METHOD FOR PRODUCING PHENYLACETAMIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110295035-A1 METHOD FOR PRODUCING PHENYLACETAMIDE COMPOUND MRPL21, AADAC, ARSA FFAR4 3251/4885FOLH1 4282/4885MAPT 3967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.