Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | PPOX | P50336 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799712 | 0.72 | MEN1 (0.36) | CASP7CYP3A4MAOALMNAMAPK1 | |
| SCHEMBL7148476 | 0.72 | MEN1 (0.43) | CASP7CYP3A4TDP1MAOAMAOB | |
| SCHEMBL9027945 | 0.71 | MAOA (0.52) | CASP3CASP2CASP7CASP6CASP8 | |
| SCHEMBL1501860 | 0.71 | MAOA (0.52) | CASP3CASP2CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL8983753 | 0.71 | GSK3B (0.94) | GSK3BCASP3CASP2CASP7CASP6 | |
| SCHEMBL15062680 | 0.70 | — | — | |
| SCHEMBL15062522 | 0.70 | — | — | |
| SCHEMBL7400922 | 0.68 | CDC25B (0.48) | CASP7CYP3A4TDP1MAOAMAOB | |
| SCHEMBL2124760 | 0.68 | CASP3 (0.47) | CASP3CASP7MAPK1HSD17B10KDM4E | |
| Phthalimide SCHEMBL11040503 | 0.68 | GSK3B (1.00) | GSK3BCASP3CASP2CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 489 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584745-B2 | Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2023-02-21 | — | — | US | claimed |
| US-20210032242-A1 | AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2021-02-04 | — | — | US | claimed |
| US-20210032241-A1 | AROMATIC HETEROCYCLIC COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2021-02-04 | — | — | US | claimed |
| US-10005787-B2 | Highly photo-stable bis-triazole fluorophores | NITTO DENKO CORPORATION (JP) | 2018-06-26 | — | — | US | claimed |
| US-20180002337-A1 | HIGHLY PHOTO-STABLE BIS-TRIAZOLE FLUOROPHORES | NITTO DENKO CORPORATION (JP) | 2018-01-04 | — | — | US | claimed |
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2016-08-04 | — | — | US | claimed |
| WO-2016112220-A1 | HIGHLY PHOTO-STABLE BIS-TRIAZOLE FLUOROPHORES | NITTO DENKO CORPORATION (JP) | 2016-07-14 | — | — | WO | claimed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | claimed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | claimed |
| US-20100056528-A1 | SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS | PHARMOS CORPORATION | 2010-03-04 | — | — | US | claimed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | claimed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | claimed |
| EP-1256574-A1 | NITROGEN-CONTAINING COMPOUNDS HAVING KINASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-11-13 | — | — | EP | claimed |
| EP-0437105-B1 | Intermediates and colorants having primary hydroxyl enriched poly(oxyalkylene) moieties and their preparation | MILLIKEN RES CORP (US) | 1996-11-13 | — | — | EP | claimed |
| US-5290921-A | Intermediates and colorants having primary hydroxyl enriched poly (oxyalkylene) moieties and their preparation | MILLIKEN RESEARCH CORPORATION (US) | 1994-03-01 | — | — | US | claimed |
| EP-0529162-A1 | Colorants and intermediates therefor having branched poly(oxyalkylene)moieties, and their manufacture | MILLIKEN RESEARCH CORPORATION (US) | 1993-03-03 | — | — | EP | claimed |
| EP-0437105-A1 | Intermediates and colorants having primary hydroxyl enriched poly(oxyalkylene) moieties and their preparation | MILLIKEN RESEARCH CORPORATION (US) | 1991-07-17 | — | — | EP | claimed |
| US-4775747-A | PIGMENTS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1988-10-04 | — | — | US | claimed |
| US-4145341-A | WATER-SOLUBLE AZO DYES CONTAINING DIAMINOPYRIMIDINE COUPLER COMPONENTS | BASF AKTIENGESELLSCHAFT (DE) | 1979-03-20 | — | — | US | claimed |
| US-4052371-A | AZO PIGMENT OR DYE HAVING A NAPHTHYL-QUINAZALONE COUPLING COMPONENT | BASF AKTIENGESELLSCHAFT (DT) | 1977-10-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056528-A1 | SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS | SULT2A1, STS, SULT1A1 | GSK3B 4242/4885CASP3 2200/4885CASP2 1389/4885 |
| US-20180002337-A1 | HIGHLY PHOTO-STABLE BIS-TRIAZOLE FLUOROPHORES | CBR3, TPD52L2, TNS4 | GSK3B 4709/4885CASP3 1020/4885CASP2 2018/4885 |
| US-20210032242-A1 | AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF | ALK, ALKBH5, ALKBH3 | GSK3B 3577/4885CASP3 3689/4885CASP2 3543/4885 |
| US-20210032241-A1 | AROMATIC HETEROCYCLIC COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | ALK, NOTUM, WEE1 | GSK3B 1080/4885CASP3 2750/4885CASP2 3346/4885 |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | TRPC4, TRPC3, TRPC1 | GSK3B 4550/4885CASP3 488/4885CASP2 1240/4885 |
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | SRC, PTK2, FYN | GSK3B 1025/4885CASP3 1505/4885CASP2 1419/4885 |
| US-10005787-B2 | Highly photo-stable bis-triazole fluorophores | CBR3, TPD52L2, TNS4 | GSK3B 4709/4885CASP3 1020/4885CASP2 2018/4885 |
| US-11584745-B2 | Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof | ALK, NOTUM, WEE1 | GSK3B 1080/4885CASP3 2750/4885CASP2 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.