SCHEMBL1572335

SCHEMBL1572335

O=Cc1ccc(Br)c(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.64
ALDH1A3 P47895 5/20 0.48
HSD17B10 Q99714 2/20 0.46
VCAM1 P19320 1/20 0.46
ALDH3A1 P30838 3/20 0.44
KDM4E B2RXH2 1/20 0.41
PTGS2 P35354 1/20 0.41
RAB9A P51151 1/20 0.41
MAPT P10636 2/20 0.39
TTR P02766 1/20 0.39
TSHR P16473 1/20 0.38
MEN1 O00255 2/20 0.37
LMNA P02545 2/20 0.37
HTT P42858 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
TYR P14679 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL671268 0.82 ALDH1A1 (0.64) ALDH1A1ALDH1A3HSD17B10VCAM1ALDH3A1
SCHEMBL29723741 0.82 ALDH1A1 (0.64) ALDH1A1ALDH1A3HSD17B10VCAM1ALDH3A1
SCHEMBL27492611 0.79 XDH (0.48) ALDH1A1ALDH1A3KDM4EMAPTMEN1
SCHEMBL29610150 0.78 ALDH1A3 (0.52) ALDH1A1ALDH1A3HSD17B10ALDH3A1KDM4E
SCHEMBL29364412 0.78 ALDH1A1 (1.00) ALDH1A1ALDH1A3HSD17B10VCAM1ALDH3A1
SCHEMBL48577 0.78 ALDH1A1 (1.00) ALDH1A1ALDH1A3HSD17B10VCAM1ALDH3A1
SCHEMBL870202 0.78 ALDH1A3 (0.52) ALDH1A1ALDH1A3HSD17B10ALDH3A1KDM4E
SCHEMBL16953710 0.77 ALDH1A1 (0.43) ALDH1A1MAPTTSHRMEN1LMNA
SCHEMBL16959459 0.77 MAPT (0.39) ALDH1A1RAB9AMAPTMEN1LMNA
Hydrochloric Acid SCHEMBL28849470 0.76 ALDH1A1 (0.95) ALDH1A1ALDH1A3HSD17B10VCAM1ALDH3A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118652153-A Method for synthesizing organic nitrile compound from aldehyde 国科大杭州高等研究院 2024-09-17 CN claimed
US-12583822-B2 Benzylamine derivative, preparation method therefor and use thereof ACADEMY OF MILITARY MEDICAL SCIENCES (CN) 2026-03-24 US disclosed
US-12583839-B2 PD-L1 antagonist compound ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2026-03-24 US disclosed
US-20260070901-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTPR LTD (GB) 2026-03-12 US disclosed
US-12534453-B2 Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof MAZE THERAPEUTICS, INC. (US) 2026-01-27 US disclosed
EP-4678641-A1 QUINOLINONE COMPOUND AND NAPHTHYRIDINONE COMPOUND AND USE THEREOF Shanghai Helioson Pharmaceutical Co., Ltd. (CN) 2026-01-14 EP disclosed
EP-4666856-A2 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO Corteva Agriscience LLC (US) 2025-12-24 EP disclosed
US-12490741-B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto CORTEVA AGRISCIENCE LLC (US) 2025-12-09 US disclosed
US-20250359552-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-11-27 US disclosed
EP-3483142-B1 AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF BEIJING MAXINOVEL PHARMACEUTICALS CO LTD (CN) 2025-10-15 EP disclosed
WO-2001066544-A2 TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 2001-09-13 WO disclosed
CN-1228778-A Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists MERZ & CO GMBH & CO (DE) 1999-09-15 CN disclosed
EP-0931081-A1 PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS MERZ + CO. GmbH & Co. (DE) 1999-07-28 EP disclosed
US-5776935-A ANTAGONISTS OF STRYCHNINE-INSENSITIVE GLYCINE SITE OF N-METHYLASPARTIC ACID RECEPTOR MERZ & CO. GMBH & CO. (DE) 1998-07-07 US disclosed
WO-1998004556-A1 PYRIDAZINO [4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS MERZ + CO. GMBH & CO. (DE) 1998-02-05 WO disclosed
US-5502073-A INSECTICIDES OR ANTHELMINTICS THE WELLCOME FOUNDATION (GB) 1996-03-26 US disclosed
CN-1025677-C Novel heterocyclic pesticidal compounds WELLCOME FOUND (GB) 1994-08-17 CN disclosed
EP-0294229-B1 NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-12-02 EP disclosed
CN-1030236-A NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS WELLCOME FOUND (GB) 1989-01-11 CN disclosed
EP-0294229-A2 Novel heterocyclic pesticidal compounds THE WELLCOME FOUNDATION LIMITED (GB) 1988-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583822-B2 Benzylamine derivative, preparation method therefor and use thereof CD274, PDCD1, PDCD1LG2 ALDH1A1 612/4885ALDH1A3 1857/4885HSD17B10 1496/4885
US-12534453-B2 Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof GYS1, GYS2, GBA1 ALDH1A1 2276/4885ALDH1A3 2742/4885HSD17B10 136/4885
US-20260070901-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CSNK1A1, CSNK2A3, CSNK1G1 ALDH1A1 3874/4885ALDH1A3 2970/4885HSD17B10 2117/4885
US-12583839-B2 PD-L1 antagonist compound CD274, PDCD1LG2, PDCD1 ALDH1A1 747/4885ALDH1A3 1146/4885HSD17B10 1460/4885
US-20250359552-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MLYCD ALDH1A1 443/4885ALDH1A3 492/4885HSD17B10 2420/4885
US-12490741-B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto ACHE, DDT, MLYCD ALDH1A1 443/4885ALDH1A3 492/4885HSD17B10 2420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.