SCHEMBL1572532

SCHEMBL1572532

CC(=O)OC[C@@H]1CCCN1C(c1ccccc1)(c1ccccc1)c1ccccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 5/20 0.42
CHRNA7 P36544 5/20 0.42
CHRNA4 P43681 5/20 0.42
CHRNA5 P30532 3/20 0.42
CYP3A4 P08684 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.38
GMNN O75496 1/20 0.38
LMNA P02545 1/20 0.38
BLM P54132 1/20 0.38
PMP22 Q01453 1/20 0.38
KMT2A Q03164 1/20 0.38
CHRM3 P20309 11/20 0.37
SLC22A1 O15245 1/20 0.36
MLNR O43193 1/20 0.36
NR1I2 O75469 1/20 0.36
TP53 P04637 1/20 0.36
ADRB2 P07550 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL1572531 0.85 LMNA (0.37) CHRNB2CHRNA7CHRNA4CHRNA5CYP3A4
SCHEMBL3486781 0.77 KCNN4 (0.41) CYP3A4SMN1; SMN2MEN1GMNNLMNA
SCHEMBL1873621 0.70 HDAC8 (0.53) CHRNB2CHRNA7CHRNA4CHRNA5CHRM3
SCHEMBL1665120 0.70 HDAC8 (0.53) CHRNB2CHRNA7CHRNA4CHRNA5CHRM3
SCHEMBL14350218 0.70 CHRNB2 (0.38) CHRNB2CHRNA7CHRNA4CHRNA5CHRM3
SCHEMBL9015291 0.67 MEN1 (0.46) CYP3A4MEN1LMNAKMT2ACHRM3
SCHEMBL7839730 0.67 MEN1 (0.46) CYP3A4MEN1LMNAKMT2ACHRM3
SCHEMBL7448432 0.67 OPRD1 (0.56) KDM4E
SCHEMBL1873957 0.66 CHRNB2 (0.64) CHRNB2CHRNA7CHRNA4CHRNA5CHRM3
SCHEMBL1878139 0.66 CHRNB2 (0.64) CHRNB2CHRNA7CHRNA4CHRNA5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS INCORPORATED 2021-05-06 US claimed
US-20160067264-A1 MEDICAMENT AND METHOD OF DIAGNOSIS UNIVERSITY OF SHEFFIELD (GB) 2016-03-10 US claimed
US-20140170768-A1 METHOD FOR MONITORING AND ASSESSING PITUITARY FUNCTION I-CALQ LLC 2014-06-19 US claimed
US-20140005158-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2014-01-02 US claimed
EP-2532350-A1 Pharmaceutical combination of a glucocorticoid receptor antagonist and a cortisol synthesis inhibitor for treating cushing's syndrome Laboratoire HRA Pharma (FR) 2012-12-12 EP claimed
US-20110224179-A1 MEDICAMENT AND METHOD OF DIAGNOSIS UNIVERSITY OF SHEFFIELD (GB) 2011-09-15 US claimed
EP-2364146-A1 MEDICAMENT AND METHOD OF DIAGNOSIS The University Of Sheffield (GB) 2011-09-14 EP claimed
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2011-07-07 US claimed
EP-2306830-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Corcept Therapeutics, Inc. (US) 2011-04-13 EP claimed
US-20100261693-A1 METHOD FOR TREATING CUSHING'S SYNDROME LABORATOIRE HRA PHARMA (FR) 2010-10-14 US claimed
WO-2009050136-A2 GLUCOCORTICOID RECEPTOR ANTAGONISTS SUCH AS MIFEPRISTONE FOR TREATING CUSHING' S SYNDROME LABORATOIRE HRA PHARMA (FR) 2009-04-23 WO claimed
EP-2012796-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 Corcept Therapeutics, Inc. (US) 2009-01-14 EP claimed
WO-2007131041-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2007-11-15 WO claimed
US-20020065259-A1 Glucocorticoid blocking agents for increasing blood-brain barrier permeability BIOPHARMA SECURED DEBT FUND II SUB, S.AR.L (LU) 2002-05-30 US claimed
WO-2002040018-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION ALCON, INC. (CH) 2002-05-23 WO claimed
WO-2002017930-A2 GLUCOCORTICOID BLOCKING AGENTS FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2002-03-07 WO claimed
US-6177427-B1 NON-STEROIDAL GLUCOCORTICOID ANTAGONISTS ALCON LABORATORIES, INC. 2001-01-23 US claimed
EP-1047410-A1 TREATMENT OF GLC1A GLAUCOMA WITH NON-STEROIDAL GLUCOCORTICOID ANTAGONISTS ALCON LABORATORIES, INC. (US) 2000-11-02 EP claimed
US-6051573-A Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists ALCON LABORATORIES, INC. (US) 2000-04-18 US claimed
WO-1999032101-A1 TREATMENT OF GLC1A GLAUCOMA WITH NON-STEROIDAL GLUCOCORTICOID ANTAGONISTS ALCON LABORATORIES, INC. (US) 1999-07-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261693-A1 METHOD FOR TREATING CUSHING'S SYNDROME MC2R, CRH, CRHR2 CHRNB2 677/4885CHRNA7 526/4885CHRNA4 1071/4885
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRHR1, NR3C1, CRH CHRNB2 790/4885CHRNA7 780/4885CHRNA4 552/4885
US-20110224179-A1 MEDICAMENT AND METHOD OF DIAGNOSIS CRH, SHBG, MC2R CHRNB2 552/4885CHRNA7 908/4885CHRNA4 849/4885
US-20160067264-A1 MEDICAMENT AND METHOD OF DIAGNOSIS CRH, SHBG, MC2R CHRNB2 631/4885CHRNA7 948/4885CHRNA4 945/4885
US-20140005158-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRHR1, NR3C1, CRH CHRNB2 790/4885CHRNA7 780/4885CHRNA4 552/4885
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS NR3C1, CRHR1, NR3C2 CHRNB2 169/4885CHRNA7 234/4885CHRNA4 149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.