Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.54 |
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | FABP3 | P05413 | 5/20 | 0.52 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29078967 | 1.00 | CA1 (0.54) | CA1DGKAFABP3CES2CES1 | |
| Potassium Ion SCHEMBL29185344 | 0.96 | FABP3 (0.55) | CA1DGKAFABP3CES2CES1 | |
| Dodecanoic Anhydride SCHEMBL18166491 | 0.94 | CA1 (0.61) | CA1DGKAFABP3CES2CES1 | |
| SCHEMBL2698113 | 0.90 | FABP3 (0.70) | FABP3LMNA | |
| Monoethanolamine SCHEMBL170506 | 0.90 | CA1 (0.44) | CA1DGKAFABP3CES2CES1 | |
| SCHEMBL446588 | 0.90 | FABP3 (0.70) | FABP3LMNA | |
| Propionic Acid SCHEMBL28471621 | 0.89 | DGKA (0.52) | CA1DGKAFABP3CES2CES1 | |
| Propionic Acid SCHEMBL28481898 | 0.89 | DGKA (0.52) | CA1DGKAFABP3CES2CES1 | |
| SCHEMBL8985011 | 0.88 | DGKA (0.64) | DGKAFABP3CES2CES1GPR84 | |
| SCHEMBL8406703 | 0.88 | DGKA (0.64) | DGKAFABP3CES2CES1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9814802-B2 | Method for promoting hair growth comprising implanting a tissue scaffold comprising CK-19 positive cells derived from Wharton's jelly mesenchymal stromal cells | THE UNIVERSITY OF KANSAS (US) | 2017-11-14 | — | — | US | disclosed |
| US-20140148915-A1 | GENERATING CK19-POSITIVE CELLS WITH HAIR-LIKE STRUCTURES FROM WHARTONS JELLY | THE CHILDREN'S MERCY HOSPITAL (US) | 2014-05-29 | — | — | US | disclosed |
| CN-101448484-B | External preparation for skin | SHISEIDO CO LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101448484-A | External preparation for skin | SHISEIDO CO LTD (JP) | 2009-06-03 | — | — | CN | disclosed |