SCHEMBL15868283

SCHEMBL15868283

CCSc1cccnc1-c1nc2cc(C(C)(F)F)cnc2n1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.40
▸ LMNA P02545 2/20 0.33
▸ RAB9A P51151 2/20 0.32
▸ USP2 O75604 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ PKM P14618 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ ALOX15 P16050 1/20 0.32
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ PTPN11 Q06124 1/20 0.30
▸ PDE10A Q9Y233 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ HDAC1 Q13547 1/20 0.30
▸ HDAC6 Q9UBN7 1/20 0.30
▸ HDAC5 Q9UQL6 1/20 0.30
▸ GRIN1 Q05586 1/20 0.30
▸ GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14676724 0.93 POLB (0.48) POLBLMNARAB9AUSP2NPC1
SCHEMBL29431603 0.93 POLB (0.48) POLBLMNARAB9AUSP2NPC1
SCHEMBL29431637 0.91 POLB (0.40) POLBLMNARAB9AUSP2NPC1
SCHEMBL14684623 0.91 POLB (0.40) POLBLMNARAB9AUSP2NPC1
SCHEMBL15868302 0.85 POLB (0.48) POLBRAB9ANPC1MEN1KMT2A
SCHEMBL15862985 0.85 LMNA (0.35) POLBLMNARAB9AUSP2NPC1
SCHEMBL15275097 0.85 AKT1 (0.40) POLBLMNARAB9AUSP2NPC1
SCHEMBL29431636 0.84 POLB (0.34) POLBLMNARAB9AUSP2NPC1
SCHEMBL14676338 0.84 POLB (0.34) POLBLMNARAB9AUSP2NPC1
SCHEMBL15868310 0.84 NPC1 (0.35) LMNARAB9ANPC1PDE10AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9974307-B2 Composition and method for controlling pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-22 — — US disclosed
US-9883675-B2 Method for controlling pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-02-06 — — US disclosed
US-9854805-B2 Composition and method for controlling pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-01-02 — — US disclosed
US-9723835-B2 Pest control composition and method for controlling pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-08-08 — — US disclosed
US-9549559-B2 Composition and method for controlling pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-01-24 — — US disclosed
US-9403771-B2 Fused heterocyclic compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-02 — — US disclosed
US-20160159743-A1 FUSED HETEROCYCLIC COMPOUND SUMITOMO CHEMICAL CO (JP) 2016-06-09 — — US disclosed
US-9353110-B2 Fused heterocyclic compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-05-31 — — US disclosed
US-20160009715-A1 FUSED HETEROCYCLIC COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-01-14 — — US disclosed
US-20150366207-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-24 — — US disclosed
US-20150366208-A1 METHOD FOR CONTROLLING PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-24 — — US disclosed
US-20150359223-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-17 — — US disclosed
US-20150359219-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-17 — — US disclosed
US-20150359222-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-17 — — US disclosed
US-9120823-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-09-01 — — US disclosed
US-20150197532-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-07-16 — — US disclosed
US-9018134-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-04-28 — — US disclosed
US-20140194290-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160159743-A1 FUSED HETEROCYCLIC COMPOUND NR0B1, NR4A1, NR0B2 POLB 4390/4885LMNA 2541/4885RAB9A 1578/4885
US-20150366207-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS NIT2, CRY1, CNPY2 POLB 4136/4885LMNA 2991/4885RAB9A 1381/4885
US-20150359222-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS TH, TCOF1, BLVRB POLB 4448/4885LMNA 3214/4885RAB9A 1555/4885
US-20140194290-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR0B1, NR4A1, NR2C2 POLB 4628/4885LMNA 1994/4885RAB9A 831/4885
US-20160009715-A1 FUSED HETEROCYCLIC COMPOUND NR0B1, NR4A1, NR0B2 POLB 4390/4885LMNA 2541/4885RAB9A 1578/4885
US-20150359223-A1 COMPOSITION AND METHOD FOR CONTROLLING PESTS PNPO, NAMPT, NNT POLB 4572/4885LMNA 3171/4885RAB9A 3572/4885
US-20150359219-A1 PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING PEST ABAT, PNPO, GABBR1 POLB 2514/4885LMNA 4447/4885RAB9A 3345/4885
US-20150366208-A1 METHOD FOR CONTROLLING PESTS BROX, RNGTT, NOS1 POLB 4136/4885LMNA 3767/4885RAB9A 1517/4885
US-20150197532-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR0B1, NR4A1, NR2C2 POLB 4628/4885LMNA 1994/4885RAB9A 831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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