Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.64 |
| ▸ | FEN1 | P39748 | 2/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | RNF4 | P78317 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofenoxyde SCHEMBL882741 | 0.92 | GSK3B (0.61) | GSK3BALDH1A1TRPA1MAPK1HIF1A | |
| SCHEMBL883109 | 0.86 | TNKS (0.58) | GSK3BALDH1A1TRPA1MAPK1HIF1A | |
| SCHEMBL8546428 | 0.85 | PKM (0.68) | GSK3BALDH1A1TRPA1MAPK1HIF1A | |
| SCHEMBL1594429 | 0.85 | MMP1 (0.64) | ERCC5FEN1MMP1PARP10RNF4 | |
| SCHEMBL15756687 | 0.85 | GSK3B (0.77) | GSK3BALDH1A1TRPA1MAPK1HIF1A | |
| SCHEMBL9814634 | 0.84 | MMP1 (0.77) | HIF1AERCC5FEN1MMP1PARP10 | |
| SCHEMBL8548986 | 0.84 | ERCC5 (0.67) | GSK3BALDH1A1TRPA1MAPK1HIF1A | |
| SCHEMBL8341053 | 0.82 | ERCC5 (0.66) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL28547033 | 0.82 | ERCC5 (0.66) | ERCC5FEN1MMP1PARP10SRD5A2 | |
| SCHEMBL5661734 | 0.82 | MMP1 (0.60) | ERCC5FEN1MMP1PARP10SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116858-B1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2020-11-11 | — | — | EP | disclosed |
| US-20170002016-A1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2017-01-05 | — | — | US | disclosed |
| US-20170002016-A1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2017-01-05 | — | — | US | disclosed |
| US-20140323501-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2014-10-30 | — | — | US | disclosed |
| US-20140323501-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2014-10-30 | — | — | US | disclosed |
| US-20140323501-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2014-10-30 | — | — | US | disclosed |
| EP-2786982-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2014-10-08 | — | — | EP | disclosed |
| EP-2786982-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013004190-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国医学科学院药物研究所 (CN) | 2013-01-10 | — | — | WO | disclosed |
| US-8217001-B2 | Modification of feeding behavior | IMPERIAL INNOVATIONS LIMITED | 2012-07-10 | — | — | US | disclosed |
| WO-2003027637-A2 | ASSESSMENT OF NEURONS IN THE ARCUATE NUCLEUS TO SCREEN FOR AGENTS THAT MODIFY FEEDING BEHAVIOR | OREGON HEALTH AND SCIENCE UNIVERSITY (US) | 2003-04-03 | — | — | WO | disclosed |
| EP-1206262-A4 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1206262-A1 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6348472-B1 | ANOREXIGENIC AGENTS AND EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-19 | — | — | US | disclosed |
| WO-2001013917-A1 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-01 | — | — | WO | disclosed |
| EP-0177463-B1 | DERIVATIVES OF 2-AMINO-THIAZOLE HAVING AN ACID SECRETION INHIBITING ACTIVITY | Medosan Industrie Biochimiche Riunite S.p.A. (IT) | 1990-12-12 | — | — | EP | disclosed |
| US-4705873-A | Derivatives of 2-amino-thiazole having an acid secretion inhibiting activity | MEDOSAN INDUSTRIE BIOCHIMICHE RIUNITE S.P.A. (IT) | 1987-11-10 | — | — | US | disclosed |
| US-4652575-A | 2-(ethylene-thio methyl furanyl)amino thiazole derivatives having acid secretion inhibiting activity | MEDOSAN INDUSTRIE BIOCHIMICHE RIUNITE S.P.A. (IT) | 1987-03-24 | — | — | US | disclosed |
| EP-0177463-A2 | Derivatives of 2-amino-thiazole having an acid secretion inhibiting activity | Medosan Industrie Biochimiche Riunite S.p.A. (IT) | 1986-04-09 | — | — | EP | disclosed |
| EP-0020970-A1 | Alpha-chloroacetophenonoxime ethers and process for their preparation | BASF Aktiengesellschaft (DE) | 1981-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170002016-A1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | TRPM8, TRPM7, TRPM5 | GSK3B 2725/4885ALDH1A1 2024/4885TRPA1 14/4885 |
| US-20140323501-A1 | AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | AADAT, HPGDS, HLA-DRB1 | GSK3B 4219/4885ALDH1A1 2654/4885TRPA1 4549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.