Sugi Predict

Sugi Predict / Compounds / SCHEMBL15940948

SCHEMBL15940948

SCHEMBL15940948

FC(F)(F)c1cc(Cl)[c]c(Cl)c1-c1c(Cl)cccc1Cl

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ HTR3E A5X5Y0 1/20 0.33
▸ HTR3B O95264 1/20 0.33
▸ HTR3A P46098 1/20 0.33
▸ HTR3D Q70Z44 1/20 0.33
▸ HTR3C Q8WXA8 1/20 0.33
▸ AR P10275 2/20 0.32
▸ PDK2 Q15119 1/20 0.32
▸ PBRM1 Q86U86 1/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ FABP4 P15090 3/20 0.30
▸ P2RX7 Q99572 2/20 0.30
▸ S1PR1 P21453 1/20 0.30
▸ TYK2 P29597 1/20 0.30
▸ ABL1 P00519 1/20 0.30
▸ TRPA1 O75762 1/20 0.30
▸ TRPM8 Q7Z2W7 1/20 0.30
▸ TRPV1 Q8NER1 1/20 0.30
▸ P2RX1 P51575 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL147649 0.71 NOTUM (0.32) —
SCHEMBL10583388 0.70 — —
SCHEMBL27260055 0.68 GLA (0.33) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL7667443 0.68 TMPRSS4 (0.32) TMPRSS4
SCHEMBL6326387 0.66 CYP1A2 (0.33) PDK2
SCHEMBL1815223 0.65 GRIA1 (0.40) ALDH1A1
SCHEMBL753312 0.65 — —
SCHEMBL10446041 0.64 ALDH1A1 (0.40) ALDH1A1ARKDM4E
SCHEMBL2471569 0.64 TSHR (0.57) ALDH1A1
SCHEMBL13728893 0.63 HSD11B1 (0.37) ARPDK2FABP4P2RX7TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3416959-B1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-05-12 — — EP claimed
US-10874104-B2 Pesticidally active pryazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-12-29 — — US claimed
US-10750742-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-25 — — US claimed
EP-3356352-B1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-08-19 — — EP claimed
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-02-13 — — US claimed
EP-3606918-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-02-12 — — EP claimed
US-10548317-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-02-04 — — US claimed
US-20190150441-A1 PESTICIDALLY ACTIVE PRYAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-05-23 — — US claimed
EP-3157913-B1 PYRAZOLYL TRIAZOLYL PYRIDINES AS PESTICIDE BAYER ANIMAL HEALTH GMBH (DE) 2019-04-17 — — EP claimed
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 — — US claimed
US-9487489-B2 Halogen-substituted pyrazole derivatives as pest-control agents BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-11-08 — — US claimed
WO-2016174049-A1 ANTI-PARASITIC COMBINATIONS INCLUDING HALOGEN-SUBSTITUTED COMPOUNDS BAYER ANIMAL HEALTH GMBH (DE) 2016-11-03 — — WO claimed
EP-2964631-A1 NOVEL HALOGEN-SUBSTITUTED COMPOUNDS Bayer Animal Health GmbH (DE) 2016-01-13 — — EP claimed
EP-2964632-A1 NOVEL HALOGEN-SUBSTITUTED COMPOUNDS Bayer CropScience Aktiengesellschaft (DE) 2016-01-13 — — EP claimed
WO-2015193216-A1 PYRAZOLYL-TRIAZOLYL-PYRIDINES AS PEST-CONTROL AGENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2015-12-23 — — WO claimed
EP-2953942-A1 HALOGEN-SUBSTITUTED PYRAZOL DERIVATIVES AS PEST-CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2015-12-16 — — EP claimed
US-20150353500-A1 HALOGEN-SUBSTITUTED PYRAZOL DERIVATIVES AS PEST-CONTROL AGENTS VETOQUINOL SA (FR) 2015-12-10 — — US claimed
WO-2014135437-A1 NOVEL HALOGEN-SUBSTITUTED COMPOUNDS BAYER CROPSCIENCE AG (DE) 2014-09-12 — — WO claimed
WO-2014135439-A1 NOVEL HALOGEN-SUBSTITUTED COMPOUNDS BAYER CROPSCIENCE AG (DE) 2014-09-12 — — WO claimed
WO-2014122083-A1 HALOGEN-SUBSTITUTED PYRAZOL DERIVATIVES AS PEST-CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2014-08-14 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150353500-A1 HALOGEN-SUBSTITUTED PYRAZOL DERIVATIVES AS PEST-CONTROL AGENTS PYM1, PRDX4, PRDX1 ALDH1A1 1200/4885SMN1; SMN2 4272/4885HTR3E 1974/4885
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT ALDH1A1 379/4885SMN1; SMN2 2261/4885HTR3E 3732/4885
US-20190150441-A1 PESTICIDALLY ACTIVE PRYAZOLE DERIVATIVES ACHE, PRXL2A, CASP7 ALDH1A1 252/4885SMN1; SMN2 1842/4885HTR3E 3594/4885
US-10548317-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, API5 ALDH1A1 265/4885SMN1; SMN2 2716/4885HTR3E 3517/4885
US-10874104-B2 Pesticidally active pryazole derivatives ACHE, PRXL2A, CASP7 ALDH1A1 252/4885SMN1; SMN2 1842/4885HTR3E 3594/4885
US-10750742-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, CAT ALDH1A1 379/4885SMN1; SMN2 2261/4885HTR3E 3732/4885
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT ALDH1A1 369/4885SMN1; SMN2 2030/4885HTR3E 3677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.