Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547161 | 0.84 | ALDH1A1 (0.60) | ALDH1A1PKMNPC1DCTPP1KAT2B | |
| SCHEMBL2550526 | 0.83 | ALDH1A1 (0.58) | ALDH1A1PKMNPC1KAT2BBRD9 | |
| SCHEMBL2549761 | 0.81 | RAB9A (0.59) | ALDH1A1PKMNPC1KAT2BBRD9 | |
| SCHEMBL20831802 | 0.80 | ALDH1A1 (0.56) | ALDH1A1PKMNPC1DCTPP1KAT2B | |
| SCHEMBL9124077 | 0.79 | PKM (0.54) | ALDH1A1PKMNPC1KAT2BBRD9 | |
| SCHEMBL23573211 | 0.75 | ALDH1A1 (0.50) | ALDH1A1PKMNPC1KAT2BBRD9 | |
| SCHEMBL9125507 | 0.69 | ALDH1A1 (0.47) | ALDH1A1PKMNPC1DCTPP1MAPT | |
| SCHEMBL27264164 | 0.69 | BPTF (0.52) | ALDH1A1PKMNPC1KAT2BMAPT | |
| SCHEMBL9125502 | 0.69 | ALDH1A1 (0.47) | ALDH1A1PKMNPC1DCTPP1MAPT | |
| SCHEMBL27263186 | 0.67 | ALDH1A1 (0.47) | ALDH1A1PKMNPC1KAT2BBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260454-B2 | Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals | SANOFI (FR) | 2016-02-16 | — | — | US | disclosed |
| US-20140296169-A1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296169-A1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | TGM2, TGM1, TGM6 | ALDH1A1 842/4885PKM 38/4885NPC1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.