SCHEMBL1614347

SCHEMBL1614347

COC(C)(OC)c1nccs1

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 10/20 0.37
ALDH1A1 P00352 2/20 0.36
TSHR P16473 1/20 0.36
NOS1 P29475 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
FBP1 P09467 3/20 0.33
PDK1 Q15118 1/20 0.33
SMPD3 Q9NY59 1/20 0.33
MAP3K14 Q99558 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12294973 0.83 ALOX5 (0.37) ALOX5ALDH1A1TSHRNOS1HSD17B10
SCHEMBL2038522 0.78 ALDH1A1 (0.36) ALOX5ALDH1A1TSHRNOS1HSD17B10
SCHEMBL684232 0.77
SCHEMBL11970362 0.75 ALOX5 (0.34) ALOX5ALDH1A1TSHRNOS1HSD17B10
SCHEMBL14152670 0.75
SCHEMBL9372859 0.75
SCHEMBL8682749 0.74 MEN1 (0.42) ALOX5ALDH1A1TSHRNOS1HSD17B10
Hydrochloric Acid SCHEMBL14889613 0.73 ALDH1A1 (0.44) ALOX5ALDH1A1TSHRNOS1HSD17B10
SCHEMBL8682794 0.73 ALDH1A1 (0.40) ALOX5ALDH1A1TSHRNOS1HSD17B10
SCHEMBL20921140 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4195928-B1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII BASF SE (DE) 2025-06-18 EP disclosed
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors INFLAZOME LIMITED (IE) 2024-07-09 US disclosed
US-20230357152-A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII BASF SE (DE) 2023-11-09 US disclosed
EP-4195928-A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII BASF SE (DE) 2023-06-21 EP disclosed
CN-116056576-A Use of strobilurin type compounds for combating phytopathogenic fungi containing F129L amino acid substitutions conferring tolerance to Qo inhibitor VIII in mitochondrial cytochrome b proteins 巴斯夫欧洲公司 2023-05-02 CN disclosed
US-20220106289-A1 NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2022-04-07 US disclosed
US-20220106289-A1 NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2022-04-07 US disclosed
EP-3970494-A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII BASF SE (DE) 2022-03-23 EP disclosed
WO-2022033906-A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII BASF SE (DE) 2022-02-17 WO disclosed
EP-3883646-A1 NLRP3 INHIBITORS Inflazome Limited (IE) 2021-09-29 EP disclosed
US-20070225232-A1 Tetrahydro-Imidazo [1,5-A] Pyridyin Derivatives as Aldosterone Synthase Inhibitors NOVARTIS AG (CH) 2007-09-27 US disclosed
EP-1749005-A1 TETRAHYDRO-IMIDAZO ¬1,5-A| PYRIDIN DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS Speedel Experimenta AG (CH) 2007-02-07 EP disclosed
EP-1605946-A2 THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES Vertex Pharmaceuticals Incorporated (US) 2005-12-21 EP disclosed
WO-2005118581-A1 TETRAHYDRO-IMIDAZO [1,5-A] PYRIDIN DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS SPEEDEL EXPERIMENTA AG (CH) 2005-12-15 WO disclosed
US-20050004150-A1 For therapy and prophylaxis of immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, proliferative disorders, immunologically-mediated diseases, or respiratory disorders VERTEX PHARMACEUTICALS INCORPORATED 2005-01-06 US disclosed
WO-2004087699-A2 THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-10-14 WO disclosed
EP-1177175-A2 HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS MERCK FROSST CANADA INC. (CA) 2002-02-06 EP disclosed
US-6200993-B1 ASTHMA; ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA & CO. (CA) 2001-03-13 US disclosed
WO-2000068198-A2 HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS MERCK FROSST CANADA & CO. (CA) 2000-11-16 WO disclosed
WO-1997046543-A1 ACETYL DERIVATIVES OF THIAZOLES AND ANALOGUES THE UNIVERSITY OF WOLLONGONG (AU) 1997-12-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors NLRP3, NOD1, NLRP1 ALOX5 353/4885ALDH1A1 1078/4885TSHR 2925/4885
US-20070225232-A1 Tetrahydro-Imidazo [1,5-A] Pyridyin Derivatives as Aldosterone Synthase Inhibitors CYP21A2, CYP11B1, REN ALOX5 415/4885ALDH1A1 430/4885TSHR 878/4885
US-20050004150-A1 For therapy and prophylaxis of immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, proliferative disorders, immunologically-mediated diseases, or respiratory disorders TSLP, JAK1, SERPINB1 ALOX5 984/4885ALDH1A1 2984/4885TSHR 4496/4885
US-20220106289-A1 NLRP3 INHIBITORS NLRP3, NLRP1, NOD1 ALOX5 1423/4885ALDH1A1 1930/4885TSHR 4765/4885
US-20230357152-A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS VIII COX5B, COX6B1, SQOR ALOX5 3549/4885ALDH1A1 4157/4885TSHR 4805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.