Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL27988712 | 0.97 | LMNA (0.50) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Acrylic Acid SCHEMBL7071287 | 0.97 | LMNA (0.56) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Acrylic Acid SCHEMBL546829 | 0.91 | ALDH1A1 (0.48) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Acrylic Acid SCHEMBL1232457 | 0.88 | ALDH1A1 (0.50) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Maleic Acid SCHEMBL1639455 | 0.87 | TSHR (0.45) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Fumaric Acid SCHEMBL1639460 | 0.87 | TSHR (0.45) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Fumaric Acid SCHEMBL16228196 | 0.84 | TSHR (0.47) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Acetic Acid SCHEMBL28514952 | 0.84 | SMN1; SMN2 (0.39) | LMNATSHRSMN1; SMN2MAPTKMT2A | |
| Maleic Acid SCHEMBL16228194 | 0.84 | TSHR (0.47) | LMNAALOX15HSD17B10TSHRSMN1; SMN2 | |
| Acrylamide SCHEMBL546914 | 0.82 | TSHR (0.55) | LMNATSHRSMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1087513-A | The hair conditioning shampoo that contains cation hair care polymer | COLGATE PALMOLIVE CO (US) | 1994-06-08 | — | — | CN | claimed |
| EP-3108872-B2 | HAIR COSMETIC | KAO CORP (JP) | 2021-09-15 | — | — | EP | disclosed |
| US-10813873-B2 | Hair cosmetic | KAO CORPORATION (JP) | 2020-10-27 | — | — | US | disclosed |
| EP-3108872-B1 | HAIR COSMETIC | KAO CORP (JP) | 2018-08-01 | — | — | EP | disclosed |
| US-20170007526-A1 | HAIR COSMETIC | KAO CORPORATION (JP) | 2017-01-12 | — | — | US | disclosed |
| EP-3108872-A1 | HAIR COSMETIC | Kao Corporation (JP) | 2016-12-28 | — | — | EP | disclosed |
| US-20120178663-A1 | DISHWASHER DETERGENT | HENKEL AG & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| US-20100163076-A1 | Method for Machine-Washing Dishes | HENKEL AG & CO. KGAA (DE) | 2010-07-01 | — | — | US | disclosed |
| US-20090029897-A1 | Detergent or Cleaning Agent | HENKEL KGAA (DE) | 2009-01-29 | — | — | US | disclosed |
| US-20080274941-A1 | DETERGENT OR CLEANSER DOSING UNIT | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-11-06 | — | — | US | disclosed |
| CN-1231204-C | Protection of cutocellulose by use of ceramides and/or glycoceramides | OREAL (FR) | 2005-12-14 | — | — | CN | disclosed |
| CN-1486683-A | Water less paste for bleaching human body keratin fiber | �ź㴫 | 2004-04-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10813873-B2 | Hair cosmetic | H1-0, H1-10, H1-5 | LMNA 2580/4885ALOX15 3248/4885HSD17B10 306/4885 |
| US-20170007526-A1 | HAIR COSMETIC | H1-0, H1-10, H1-5 | LMNA 2580/4885ALOX15 3248/4885HSD17B10 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.