Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168203 | 0.84 | TUBB4A (0.43) | LMNATP53MAPTTHRBNTRK1 | |
| SCHEMBL167755 | 0.79 | IRAK4 (0.39) | MAPTHAO2 | |
| SCHEMBL166629 | 0.68 | CDC7 (0.39) | MAPK1LMNATP53MAPTTHRB | |
| SCHEMBL28287263 | 0.66 | IKBKB (0.47) | LMNAMAPT | |
| SCHEMBL20075097 | 0.66 | SLC34A1 (0.47) | MAPK1TP53MAPTTHRBNTRK1 | |
| SCHEMBL7989696 | 0.66 | ALOX5 (0.47) | LMNATP53MAPTCHEK2 | |
| SCHEMBL164282 | 0.66 | NPC1 (0.47) | MALT1LMNAPARP1 | |
| SCHEMBL20074772 | 0.65 | HAO2 (0.42) | MAPK1MAPTHAO2 | |
| SCHEMBL20075637 | 0.65 | GABRA2 (0.43) | MAPK1LMNAMAPT | |
| SCHEMBL4964605 | 0.65 | HAO2 (0.53) | LMNAMAPTHAO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |