Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.32 |
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.32 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.32 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353521 | 0.88 | CA2 (0.38) | CA4CA2 | |
| SCHEMBL6343639 | 0.84 | CRAT (0.35) | CA4CA2 | |
| SCHEMBL1766228 | 0.84 | LMNA (0.44) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| SCHEMBL3840956 | 0.74 | GABRR1 (0.43) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| SCHEMBL8961847 | 0.72 | LMNA (0.41) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| SCHEMBL4917915 | 0.72 | LMNA (0.41) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| Ammonia Solution, Strong SCHEMBL1766158 | 0.68 | GABRR1 (0.32) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| SCHEMBL10940119 | 0.65 | GABRR1 (0.43) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| SCHEMBL28072269 | 0.65 | MME (0.36) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| Potassium Ion SCHEMBL15147689 | 0.64 | CA2 (0.37) | LMNAADRA1ACA4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120252-B2 | Molded article and method for production thereof | KURARAY CO., LTD. (JP) | 2015-09-01 | — | — | US | disclosed |
| EP-1479725-B1 | RESIN COMPOSITION AND MULTI-LAYER STRUCTURES | KURARAY CO (JP) | 2014-05-14 | — | — | EP | disclosed |
| EP-2174981-B1 | Resin composition and multi-layer structures | KURARAY CO (JP) | 2013-07-24 | — | — | EP | disclosed |
| US-8329818-B2 | Modified ethylene-vinyl alcohol copolymer and method for the production thereof | KURARAY CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110097527-A1 | MOLDED ARTICLE AND METHOD FOR PRODUCTION THEREOF | KURARAY CO., LTD (JP) | 2011-04-28 | — | — | US | disclosed |
| US-20100280178-A1 | MODIFIED ETHYLENE-VINYL ALCOHOL COPOLYMER AND METHOD FOR THE PRODUCTION THEREOF | KURARAY CO., LTD. (JP) | 2010-11-04 | — | — | US | disclosed |
| US-7811646-B2 | Modified ethylene-vinyl alcohol copolymer and method for the production thereof | KURARAY CO., LTD. (JP) | 2010-10-12 | — | — | US | disclosed |
| EP-2174981-A1 | Resin composition and multi-layer structures | Kuraray Co., Ltd. (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1403289-B1 | MODIFIED ETHYLENE -VINYL ALCOHOL COPOLYMER AND METHOD FOR THE PRODUCTION THEREOF | KURARAY CO (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-7534829-B2 | Resin composition and multi-layer structures | KURARAY CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| EP-2028220-A1 | MOLDED ARTICLE AND METHOD FOR PRODUCTION THEREOF | Kuraray Co., Ltd. (JP) | 2009-02-25 | — | — | EP | disclosed |
| US-20050147778-A1 | Resin composition and multi-layer structures | KURARAY CO., LTD. (JP) | 2005-07-07 | — | — | US | disclosed |
| EP-1479725-A1 | RESIN COMPOSITION AND MULTI-LAYER STRUCTURES | Kuraray Co., Ltd. (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-20040096683-A1 | Modified ethylene-vinyl alcohol copolymer and method for the production thereof | KURARAY CO., LTD. (JP) | 2004-05-20 | — | — | US | disclosed |
| EP-1403289-A1 | MODIFIED ETHYLENE−VINYL ALCOHOL COPOLYMER AND METHOD FOR THE PRODUCTION THEREOF | Kuraray Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |