SCHEMBL1644285

SCHEMBL1644285

CCCC[C@H](N)C(=O)N(NC(=O)COc1ccc(CN(C(=O)OCC2c3ccccc3-c3ccccc32)c2ccc(OC)cc2OC)cc1)C(c1ccccc1)c1ccc(C)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ BMP1 P13497 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ TSHR P16473 1/20 0.32
▸ POLB P06746 2/20 0.32
▸ MAPT P10636 3/20 0.31
▸ TP53 P04637 2/20 0.31
▸ SMN1; SMN2 Q16637 2/20 0.31
▸ MDM2 Q00987 2/20 0.31
▸ LMNA P02545 2/20 0.31
▸ ATM Q13315 1/20 0.31
▸ PKM P14618 1/20 0.31
▸ NR1H3 Q13133 1/20 0.31
▸ LTB4R2 Q9NPC1 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ LPAR1 Q92633 1/20 0.30
▸ LPAR2 Q9HBW0 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7185186 0.88 NPC1 (0.34) MEN1KMT2ABMP1NPC1RAB9A
SCHEMBL8079493 0.84 MEN1 (0.40) MEN1KMT2ANPC1RAB9ATSHR
SCHEMBL2990766 0.83 MEN1 (0.43) MEN1KMT2ANPC1RAB9ATSHR
Norleucine SCHEMBL7204454 0.83 SLC1A5 (0.36) MEN1KMT2ABMP1NPC1RAB9A
SCHEMBL18304267 0.81 NPC1 (0.39) MEN1KMT2ANPC1RAB9ATSHR
SCHEMBL7815464 0.80 BMP1 (0.33) MEN1KMT2ABMP1NPC1RAB9A
SCHEMBL5330706 0.79 NPC1 (0.36) MEN1KMT2ABMP1NPC1RAB9A
SCHEMBL7557772 0.79 NPC1 (0.35) MEN1KMT2ABMP1NPC1RAB9A
SCHEMBL3386401 0.78 MDM2 (0.41) MEN1KMT2ANPC1RAB9AMDM2
SCHEMBL17500350 0.78 NPC1 (0.43) MEN1KMT2ANPC1RAB9ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139257-A1 PLIN1 RNAi INTERFERENCE AGENTS ELI LILLY AND CO (US) 2026-05-21 — — US disclosed
US-20240174727-A1 LONG-ACTING NATRIURETIC PEPTIDES AND USES THEREOF ELI LILLY AND COMPANY 2024-05-30 — — US disclosed
WO-2024086680-A2 LONG-ACTING NATRIURETIC PEPTIDES AND USES THEREOF ELI LILLY AND COMPANY (US) 2024-04-25 — — WO disclosed
EP-2252628-B1 BOMBESIN ANALOG PEPTIDE ANTAGONIST CONJUGATES UNIVERSITÄTSSPITAL BASEL (CH) 2016-12-28 — — EP disclosed
US-9035023-B2 Bombesin analog peptide antagonist conjugates Piramal Imaging, SA (CH) 2015-05-19 — — US disclosed
US-20110097266-A1 Bombesin Analog Peptide Antagonist Conjugates BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-04-28 — — US disclosed
EP-1789436-B1 ANTIBACTERIAL PEPTIDES AND ANALOGUES THEREOF UNIV SIENA (IT) 2009-12-16 — — EP disclosed
WO-2003025001-A1 MULTIPLE ANTIGEN PEPTIDES (MAP) AS ANTIDOTES AGAINST SNAKE NEUROTOXIN INTOXICATION UNIVERSITA' DEGLI STUDI DI SIENA (IT) 2003-03-27 — — WO disclosed
EP-0846127-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY Novartis AG (CH) 1998-06-10 — — EP disclosed
WO-1997008193-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY NOVARTIS AG (CH) 1997-03-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110097266-A1 Bombesin Analog Peptide Antagonist Conjugates BRS3, VIP, GRPR MEN1 52/4885KMT2A 3479/4885BMP1 81/4885
US-20260139257-A1 PLIN1 RNAi INTERFERENCE AGENTS PLIN1, PLIN3, PLIN5 MEN1 3617/4885KMT2A 1621/4885BMP1 1921/4885
US-20240174727-A1 LONG-ACTING NATRIURETIC PEPTIDES AND USES THEREOF NPPA, NPR1, NPR3 MEN1 867/4885KMT2A 4736/4885BMP1 598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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