Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9486052 | 0.85 | ALDH1A1 (0.49) | CA2CA1CA9CA12ALDH1A1 | |
| SCHEMBL18493829 | 0.79 | BCAT1 (0.54) | CA2CA1CA9CA12KEAP1 | |
| SCHEMBL8764610 | 0.78 | CCR2 (0.44) | CA2CCR2CA1CA9CA12 | |
| SCHEMBL1419067 | 0.77 | KDM4E (0.45) | CA2CA9CA12FLT3CYP2A6 | |
| SCHEMBL1081207 | 0.76 | HDAC3 (0.43) | MAOAKDM4EMAOBTAS1R3TAS1R1 | |
| SCHEMBL28643561 | 0.74 | CYP2A6 (0.47) | CA2CA1CA9CA12FLT3 | |
| SCHEMBL10823736 | 0.73 | NPC1 (0.54) | CA1CA9CA12FLT3ALDH1A1 | |
| SCHEMBL16985241 | 0.72 | CA2 (0.67) | CA2CCR2CA1CA9CA12 | |
| SCHEMBL8764646 | 0.72 | CYP2D6 (0.51) | FLT3CYP2A6ALDH1A1MAOAKDM4E | |
| SCHEMBL28279168 | 0.72 | KMT2A (0.49) | ALDH1A1KDM4ERXFP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562912-B2 | Heterocyclic derivatives and use thereof | C&C RESEARCH LABORATORIES (KR) | 2020-02-18 | — | — | US | disclosed |
| CN-105753822-B | A kind of benzofuran derivative, its preparation method and application | 华润赛科药业有限责任公司 | 2018-04-03 | — | — | CN | disclosed |
| US-9334254-B2 | Process for preparing sulfonamidobenzofuran derivatives | SANOFI (FR) | 2016-05-10 | — | — | US | disclosed |
| US-20160108056-A1 | HETEROCYCLIC DERIVATIVES AND USE THEREOF | C&C RESEARCH LABORATORIES (KR) | 2016-04-21 | — | — | US | disclosed |
| CN-102933568-A | Procede de preparation de derives de sulfonamido-benzofurane | SANOFI AVENTIS | 2013-02-13 | — | — | CN | disclosed |
| EP-2552900-A1 | PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-02-06 | — | — | EP | disclosed |
| EP-2552899-A1 | PROCESS FOR PREPARING SULFONAMIDO-BENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-02-06 | — | — | EP | disclosed |
| CN-102906081-A | Process for preparing aminobenzofuran derivatives | SANOFI AVENTIS | 2013-01-30 | — | — | CN | disclosed |
| US-20130023677-A1 | PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| US-20130023678-A1 | PROCESS FOR PREPARING SULFONAMIDOBENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-01-24 | — | — | US | disclosed |
| CN-1479735-A | Methanesulphonamido-benzofuran derivative, preparation method and use thereof as synthesis ntermediate | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-03-03 | — | — | CN | disclosed |
| US-20040010032-A1 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof | SANOFI (FR) | 2004-01-15 | — | — | US | disclosed |
| EP-1351907-A1 | 2-BUTYL-3-(4- 3(DIBUTYLAMINO)PROPOXY BENZOYL)-5-NITRO-BENZOFURAN HYDROCHLORIDE AND PREPARATION THEREOF | Sanofi-Aventis (FR) | 2003-10-15 | — | — | EP | disclosed |
| EP-1343473-A1 | PHARMACEUTICAL DRONEDARONE COMPOSITION FOR PARENTERAL ADMINISTRATION | Sanofi-Aventis (FR) | 2003-09-17 | — | — | EP | disclosed |
| EP-1343777-A1 | METHANESULPHONAMIDO-BENZOFURAN, PREPARATION METHOD AND USE THEREOF AS SYNTHESIS INTERMEDIATE | SANOFI-SYNTHELABO (FR) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002048078-A1 | 2-BUTYL-3-(4-[3(DIBUTYLAMINO)PROPOXY]BENZOYL)-5-NITRO-BENZOFURAN HYDROCHLORIDE AND PREPARATION THEREOF | SANOFI-SYNTHELABO (FR) | 2002-06-20 | — | — | WO | disclosed |
| WO-2002047660-A1 | PHARMACEUTICAL DRONEDARONE COMPOSITION FOR PARENTERAL ADMINISTRATION | SANOFI-SYNTHELABO (FR) | 2002-06-20 | — | — | WO | disclosed |
| WO-2002048132-A1 | METHANESULPHONAMIDO-BENZOFURAN, PREPARATION METHOD AND USE THEREOF AS SYNTHESIS INTERMEDIATE | SANOFI-SYNTHELABO (FR) | 2002-06-20 | — | — | WO | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023677-A1 | PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES | CYP2F1, F5, F12 | CA2 2008/4885CCR2 4707/4885CA1 2475/4885 |
| US-20160108056-A1 | HETEROCYCLIC DERIVATIVES AND USE THEREOF | STAT3, JAK2, STAT5A | CA2 1985/4885CCR2 860/4885CA1 3407/4885 |
| US-20130023678-A1 | PROCESS FOR PREPARING SULFONAMIDOBENZOFURAN DERIVATIVES | CYP2F1, STS, SULT1E1 | CA2 1179/4885CCR2 294/4885CA1 1532/4885 |
| US-10562912-B2 | Heterocyclic derivatives and use thereof | STAT3, JAK2, STAT5A | CA2 1985/4885CCR2 860/4885CA1 3407/4885 |
| US-20040010032-A1 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof | CYP2D6, DBF4, DUT | CA2 3952/4885CCR2 4592/4885CA1 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.