Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | GGH | Q92820 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17933364 | 0.80 | GRIA1 (0.42) | — | |
| SCHEMBL17933369 | 0.72 | ACHE (0.36) | ACHE | |
| SCHEMBL17933331 | 0.72 | ACHE (0.38) | ACHE | |
| SCHEMBL18534192 | 0.70 | ITGA4 (0.38) | MDM4TP53 | |
| SCHEMBL18534153 | 0.69 | MAPT (0.39) | — | |
| SCHEMBL17933380 | 0.69 | GRIA1 (0.41) | ACHE | |
| SCHEMBL16553933 | 0.67 | ITGB1 (0.37) | GGH | |
| SCHEMBL18179099 | 0.66 | L3MBTL1 (0.53) | — | |
| SCHEMBL16554003 | 0.65 | ITGB1 (0.35) | GGH | |
| SCHEMBL17936290 | 0.64 | GRIA1 (0.37) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | UNIVERSITY OF SHEFFIELD (GB) | 2018-08-21 | — | — | US | disclosed |
| EP-2976346-B1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIV SHEFFIELD (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2016-07-21 | — | — | US | disclosed |
| EP-2976346-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | University of Sheffield (GB) | 2016-01-27 | — | — | EP | disclosed |
| WO-2015033120-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIVERSITY OF SHEFFIELD (GB) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207948-A1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | HRH3, CYTH3, CYTH2 | GRN 2441/4885SORT1 4362/4885MDM4 854/4885 |
| US-10053476-B2 | Phosphohistidine and phosphotyrosine analogues | HRH3, CYTH3, CYTH2 | GRN 2551/4885SORT1 4378/4885MDM4 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.