Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28328623 | 0.93 | TRPM8 (0.55) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL16456973 | 0.81 | EPHX1 (0.49) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL112766 | 0.81 | EPHX1 (0.49) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL851820 | 0.80 | EPHX1 (0.51) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Bicarbonate SCHEMBL1660906 | 0.79 | EPHX1 (0.47) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Hydrochloric Acid SCHEMBL11492237 | 0.79 | EPHX1 (0.50) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Bicarbonate SCHEMBL28645655 | 0.78 | EPHX1 (0.46) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL9951257 | 0.78 | EPHX1 (0.53) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL3274993 | 0.78 | EPHX1 (0.53) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL1030886 | 0.78 | EPHX1 (0.53) | EPHX1TRPM8TRPA1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250352444-A1 | Antimicrobial mixtures | SYMRISE AG (DE) | 2025-11-20 | — | — | US | claimed |
| EP-4525822-A1 | ANTIMICROBIAL MIXTURES | Symrise AG (DE) | 2025-03-26 | — | — | EP | claimed |
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | SYMRISE AG (DE) | 2024-02-22 | — | — | US | claimed |
| WO-2023222577-A1 | ANTIMICROBIAL MIXTURES | SYMRISE AG (DE) | 2023-11-23 | — | — | WO | claimed |
| WO-2023222213-A1 | ANTIMICROBIAL MIXTURES | SYMRISE AG (DE) | 2023-11-23 | — | — | WO | claimed |
| EP-4259287-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | Symrise AG (DE) | 2023-10-18 | — | — | EP | claimed |
| EP-3081207-B1 | USE OF A LIPOSOME COMPOSITION | SYMRISE AG (DE) | 2022-09-21 | — | — | EP | claimed |
| WO-2022122144-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| EP-3142499-B1 | HOMOVANILLIC ACID ESTERS, IN PARTICULAR FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS | SYMRISE AG (DE) | 2019-10-30 | — | — | EP | claimed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| US-20190099342-A1 | COOLING PRODUCT | SYMRISE AG (DE) | 2019-04-04 | — | — | US | claimed |
| WO-2016166038-A1 | WHITENING COMPOSITIONS | SYMRISE AG (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3081207-A1 | WHITENING COMPOSITIONS | Symrise AG (DE) | 2016-10-19 | — | — | EP | claimed |
| EP-4192614-B1 | PROCESS FOR THE PREPARATION OF MICROCAPSULES | SYMRISE AG (DE) | 2026-05-06 | — | — | EP | disclosed |
| EP-4725476-A2 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | Firmenich SA (CH) | 2026-04-15 | — | — | EP | disclosed |
| EP-4096714-B1 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | FIRMENICH & CIE (CH) | 2026-01-28 | — | — | EP | disclosed |
| US-20080096969-A1 | N alpha-(Menthanecarbonyl)amino acid amides and use thereof as physiological cooling active ingredients | SYMRISE GMBH & CO. KG (DE) | 2008-04-24 | — | — | US | disclosed |
| WO-2007138031-A2 | MENTHANE CARBOXYLIC ACID N-(ALKYLTHIOALKYL)AMIDES AND USE THEREOF AS PHYSIOLOGICALLY ACTIVE COOLING ACTIVE INGREDIENTS | SYMRISE GMBH & CO. KG (DE) | 2007-12-06 | — | — | WO | disclosed |
| US-20070202188-A1 | Use of alkene carboxlic acid n alkylamides as flavouring agents | SYMRISE GMBH & CO. KG (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099342-A1 | COOLING PRODUCT | TRPA1, TRPV2, NISCH | EPHX1 1636/4885TRPM8 44/4885TRPA1 1/4885 |
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | MGLL, GCDH, GK | EPHX1 1246/4885TRPM8 84/4885TRPA1 187/4885 |
| US-20250352444-A1 | Antimicrobial mixtures | LRBA, MGLL, TAS2R50 | EPHX1 3703/4885TRPM8 205/4885TRPA1 71/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | EPHX1 4010/4885TRPM8 1/4885TRPA1 8/4885 |
| US-20070202188-A1 | Use of alkene carboxlic acid n alkylamides as flavouring agents | TAS2R41, TAS2R1, TAS2R14 | EPHX1 2042/4885TRPM8 640/4885TRPA1 34/4885 |
| US-20080096969-A1 | N alpha-(Menthanecarbonyl)amino acid amides and use thereof as physiological cooling active ingredients | NMBR, RIMKLA, NAAA | EPHX1 2078/4885TRPM8 86/4885TRPA1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.