Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31148535 | 0.93 | TRPM8 (0.52) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL19209892 | 0.80 | EPHX1 (0.47) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL1030881 | 0.80 | EPHX1 (0.44) | EPHX1TRPM8TRPA1CYP19A1ALDH1A1 | |
| SCHEMBL21380098 | 0.79 | TRPM8 (0.48) | EPHX1TRPM8TRPA1CYP19A1ALDH1A1 | |
| SCHEMBL1862576 | 0.79 | TRPM8 (0.48) | EPHX1TRPM8TRPA1CYP19A1ALDH1A1 | |
| Bicarbonate SCHEMBL1660899 | 0.79 | EPHX1 (0.50) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL31152467 | 0.79 | TRPM8 (0.48) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Levomenthol SCHEMBL2960650 | 0.79 | TRPM8 (0.68) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Menthol SCHEMBL583835 | 0.79 | TRPM8 (0.68) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| Menthol SCHEMBL2634088 | 0.78 | TRPM8 (0.66) | EPHX1TRPM8TRPA1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260047994-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | SYMRISE AG (DE) | 2026-02-19 | — | — | US | claimed |
| US-20250352444-A1 | Antimicrobial mixtures | SYMRISE AG (DE) | 2025-11-20 | — | — | US | claimed |
| US-20250325463-A1 | COMPOSITIONS (III) | SYMRISE AG (DE) | 2025-10-23 | — | — | US | claimed |
| EP-4622621-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | Symrise AG (DE) | 2025-10-01 | — | — | EP | claimed |
| CN-120129464-A | Flavonoid compound and application thereof | 弗门尼舍有限公司 | 2025-06-10 | — | — | CN | claimed |
| EP-4251122-B1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-03-12 | — | — | EP | claimed |
| EP-4472606-A1 | COMPOSITIONS (III) | Symrise AG (DE) | 2024-12-11 | — | — | EP | claimed |
| US-20240358611-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2024-10-31 | — | — | US | claimed |
| EP-4429465-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | Symrise AG (DE) | 2024-09-18 | — | — | EP | claimed |
| US-20240225915-A1 | COMPOSITIONS FOR FIGHTING MALODORS | SYMRISE AG (DE) | 2024-07-11 | — | — | US | claimed |
| WO-2022122903-A1 | COMPOSITIONS COMPRISING (BIO)-ALKANEDIOLS AND COOLING AGENTS | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| WO-2022122134-A1 | COMPOSITIONS WITH (BIO)-ALKANEDIOLS AND COOLING AGENTS | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| EP-3996506-A1 | FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS | Bedoukian Research, Inc. (US) | 2022-05-18 | — | — | EP | claimed |
| EP-3996505-A1 | SYNERGISTIC FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS | Bedoukian Research, Inc. (US) | 2022-05-18 | — | — | EP | claimed |
| EP-3687311-A1 | AMIDES FOR GENERATING A TRIGEMINAL EFFECT | Symrise AG (DE) | 2020-08-05 | — | — | EP | claimed |
| EP-3142499-B1 | HOMOVANILLIC ACID ESTERS, IN PARTICULAR FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS | SYMRISE AG (DE) | 2019-10-30 | — | — | EP | claimed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| US-20190099342-A1 | COOLING PRODUCT | SYMRISE AG (DE) | 2019-04-04 | — | — | US | claimed |
| WO-2016166038-A1 | WHITENING COMPOSITIONS | SYMRISE AG (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3081207-A1 | WHITENING COMPOSITIONS | Symrise AG (DE) | 2016-10-19 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099342-A1 | COOLING PRODUCT | TRPA1, TRPV2, NISCH | EPHX1 1636/4885TRPM8 44/4885TRPA1 1/4885 |
| US-20240358611-A1 | COMPOSITIONS | AZI2, NISCH, CIP2A | EPHX1 2269/4885TRPM8 168/4885TRPA1 17/4885 |
| US-20250352444-A1 | Antimicrobial mixtures | LRBA, MGLL, TAS2R50 | EPHX1 3703/4885TRPM8 205/4885TRPA1 71/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | EPHX1 4010/4885TRPM8 1/4885TRPA1 8/4885 |
| US-20260047994-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | RBP4, LRAT, RARB | EPHX1 721/4885TRPM8 1615/4885TRPA1 3243/4885 |
| US-20250325463-A1 | COMPOSITIONS (III) | NISCH, TAS1R3, TAS2R3 | EPHX1 3052/4885TRPM8 171/4885TRPA1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.