Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612923 | 0.78 | LTA4H (0.43) | HPGDRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16612797 | 0.78 | HCRTR2 (0.40) | ALDH1A1KMT2AMEN1HPGDGAA | |
| SCHEMBL10644754 | 0.70 | ALDH1A1 (0.73) | DDAH1ADRA2CALDH1A1KMT2AMEN1 | |
| SCHEMBL12479730 | 0.70 | DDAH1 (0.57) | DDAH1ADRA2CALDH1A1KMT2AMEN1 | |
| SCHEMBL16612915 | 0.70 | APAF1 (0.45) | ALDH1A1KMT2AHTTTSHRTDP1 | |
| SCHEMBL6271552 | 0.69 | KMT2A (0.63) | DDAH1ADRA2CALDH1A1KMT2AMEN1 | |
| SCHEMBL16612739 | 0.69 | TDP1 (0.54) | ALDH1A1HTTHPGDTSHRTDP1 | |
| SCHEMBL14699373 | 0.68 | ADORA2A (0.47) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL16612954 | 0.68 | LMNA (0.53) | KMT2AHTTTSHRMAPK1HSD17B10 | |
| SCHEMBL10764766 | 0.67 | MEN1 (0.60) | DDAH1ADRA2CALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |