Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612770 | 0.92 | ADRB2 (0.44) | ADRB2MTNR1AMTNR1BNQO2HTR6 | |
| SCHEMBL16612684 | 0.83 | HTR2A (0.49) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL12479180 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2HTR6MEN1 | |
| SCHEMBL16612679 | 0.79 | HTR2A (0.52) | MTNR1AMTNR1BHTR6HCRTR1HCRTR2 | |
| SCHEMBL16612943 | 0.76 | SIGMAR1 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL16612868 | 0.76 | MTNR1A (0.49) | MTNR1AMTNR1BHCRTR1HCRTR2RAB9A | |
| SCHEMBL16612854 | 0.73 | MTNR1A (0.52) | MTNR1AMTNR1BHCRTR1HCRTR2MEN1 | |
| SCHEMBL18509701 | 0.73 | MTNR1A (0.67) | ADRB2MTNR1AMTNR1BNQO2HTR6 | |
| SCHEMBL12479701 | 0.73 | ADRB2 (0.63) | ADRB2MTNR1AMTNR1BNQO2HTR6 | |
| SCHEMBL16612856 | 0.72 | MTNR1A (0.54) | MTNR1AMTNR1BHCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |