Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735667 | 0.86 | POLB (0.51) | MAPTTP53RXFP1ALDH1A1HPGD | |
| SCHEMBL16735578 | 0.84 | POLB (0.56) | MAPTTP53RXFP1LMNAALDH1A1 | |
| SCHEMBL16735620 | 0.82 | KCNH2 (0.45) | TP53RXFP1LMNAALDH1A1HPGD | |
| SCHEMBL16735639 | 0.81 | RXFP1 (0.46) | RXFP1LMNAPOLB | |
| SCHEMBL16735634 | 0.81 | KDM4C (0.54) | MAPTRXFP1SMN1; SMN2POLBNPC1 | |
| SCHEMBL16735663 | 0.81 | RXFP1 (0.45) | RXFP1LMNAPOLB | |
| SCHEMBL16735647 | 0.80 | POLB (0.49) | MAPTRXFP1LMNAALDH1A1POLB | |
| SCHEMBL16735658 | 0.79 | POLB (0.53) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL16735680 | 0.79 | POLB (0.42) | TP53RXFP1RECQLALDH1A1HPGD | |
| SCHEMBL16735649 | 0.79 | POLB (0.46) | MAPTRXFP1RECQLLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |