Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898090 | 0.85 | LTA4H (0.45) | HTR1AMGAMGAASIMGAM2 | |
| SCHEMBL16740415 | 0.85 | MAOA (0.39) | HTR1AADRA1DADRA1AADRA1BGAA | |
| SCHEMBL16744462 | 0.83 | HTR1A (0.38) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL5583748 | 0.83 | KDM4E (0.49) | HTR1AADRA1DADRA1AADRA1BMGAM | |
| Hydrochloric Acid SCHEMBL10371618 | 0.81 | KDM4E (0.51) | HTR1AADRA1DADRA1AADRA1BMGAM | |
| SCHEMBL15088139 | 0.81 | HTR1A (0.38) | HTR1AADRA1DADRA1AADRA1BGAA | |
| SCHEMBL16740342 | 0.81 | AR (0.38) | HTR1AADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL16740381 | 0.80 | RAB9A (0.40) | GAAKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL16740382 | 0.80 | RAB9A (0.40) | GAAKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4684239 | 0.80 | MGAM (0.44) | HTR1AADRA1DADRA1AADRA1BMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010535-B2 | Desferrithiocin analogs and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-07-03 | — | — | US | disclosed |
| US-10010535-B2 | Desferrithiocin analogs and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-07-03 | — | — | US | disclosed |
| US-10010535-B2 | Desferrithiocin analogs and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-07-03 | — | — | US | disclosed |
| US-20160289223-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-10-06 | — | — | US | disclosed |
| US-20160289223-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-10-06 | — | — | US | disclosed |
| US-20160289223-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-10-06 | — | — | US | disclosed |
| EP-3071201-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | University of Florida Research Foundation, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015077655-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
| WO-2015077655-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10010535-B2 | Desferrithiocin analogs and uses thereof | FECH, TFRC, FTH1 | HTR1A 2922/4885ADRA1D 608/4885ADRA1A 1850/4885 |
| US-20160289223-A1 | DESFERRITHIOCIN ANALOGS AND USES THEREOF | FECH, TFRC, FTH1 | HTR1A 2922/4885ADRA1D 608/4885ADRA1A 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.