Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039308 | 0.92 | CYP1A2 (0.46) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL1940101 | 0.89 | CYP1A2 (0.63) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL1039309 | 0.87 | CYP1A2 (0.61) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL1039306 | 0.87 | CYP1A2 (0.61) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL11421652 | 0.80 | ALDH1A1 (0.56) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL25211288 | 0.80 | ALDH1A1 (0.59) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL32672522 | 0.80 | ALDH1A1 (0.59) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL22372331 | 0.80 | CTRB1 (0.46) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL27898864 | 0.80 | CYP2D6 (0.60) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL17707250 | 0.80 | CYP1A2 (0.55) | CYP1A2ALDH1A1MEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928150-B2 | Process for the manufacture of lonomeric polybutylene terephthalate from polyethylene terephthalate, and compositions and articles thereof | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-04-19 | — | — | US | disclosed |
| US-20090281204-A1 | Process for the Manufacture of Ionomeric Polybutylene Terephthalate From Polyethylene Terephthalate, and Compositions and Articles Thereof | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2009-11-12 | — | — | US | disclosed |
| EP-1302309-B1 | Multi-layer, weatherable compositions and method of manufacture thereof | GEN ELECTRIC (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1373361-B1 | POLYESTER IONOMER COMPOSITION | GEN ELECTRIC (US) | 2008-06-25 | — | — | EP | disclosed |
| EP-1414903-B1 | POLYESTER POLYAMIDE MOLDING COMPOSITION | GEN ELECTRIC (US) | 2007-12-05 | — | — | EP | disclosed |
| US-7090926-B2 | Multi-layer, weatherable compositions and method of manufacture thereof | GENERAL ELECTRIC COMPANY (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1165692-B1 | POLYESTER MOLDING COMPOSITION | GEN ELECTRIC (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1185576-B1 | POLYESTER MOLDING COMPOSITION | GEN ELECTRIC (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1414903-A1 | POLYESTER POLYAMIDE MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1373361-A2 | POLYESTER IONOMER COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002050157-A2 | POLYESTER IONOMER COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
| US-20020082381-A1 | Polyester molding composition | GENERAL ELECTRIC COMPANY | 2002-06-27 | — | — | US | disclosed |
| EP-1185576-A1 | POLYESTER MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-1165692-A1 | POLYESTER MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6300405-B2 | MOLD FLOW, SHEAR SENSITIVITY, TENSILE STRENGTH, AND FLEXUAL MODULUS | GENERAL ELECTRIC COMPANY | 2001-10-09 | — | — | US | disclosed |
| US-20010009944-A1 | POLYESTER MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY | 2001-07-26 | — | — | US | disclosed |
| WO-2000049089-A1 | POLYESTER MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2000-08-24 | — | — | WO | disclosed |
| US-6066694-A | IONOMER POLYESTERS, MIXED WITH POLYESTER CARBONATES, POLYARYLATES OR POLYCARBONATES GIVE BLENDS HIGH GLASS TRANSITION TEMPERATURE, THUS IMPROVED DIMENSIONAL STABILITY, AT HIGHER TEMPERATURE | GENERAL ELECTRIC COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| WO-2000000534-A1 | POLYESTER MOLDING COMPOSITION | GENERAL ELECTRIC COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |
| EP-0940443-A2 | Polyester molding composition | GENERAL ELECTRIC COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |