SCHEMBL168370

SCHEMBL168370

CNS(=O)(=O)c1cccc(OC(F)F)c1C#N

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 6/20 0.40
CCR4 P51679 1/20 0.37
EPAS1 Q99814 3/20 0.36
ALDH1A1 P00352 1/20 0.35
PTGES2 Q9H7Z7 1/20 0.34
MAPT P10636 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
VEGFA P15692 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29572114 1.00 SLC22A12 (0.40) SLC22A12CCR4EPAS1ALDH1A1PTGES2
SCHEMBL29572421 0.85 SLC22A12 (0.38) SLC22A12CCR4EPAS1ALDH1A1PTGES2
SCHEMBL168868 0.85 SLC22A12 (0.38) SLC22A12CCR4EPAS1ALDH1A1PTGES2
SCHEMBL15461580 0.84 EPAS1 (0.45) SLC22A12EPAS1PTGES2VEGFA
SCHEMBL14844360 0.84 SLC22A12 (0.39) SLC22A12ALDH1A1PTGES2L3MBTL1
SCHEMBL5323794 0.83 SLC22A12 (0.39) SLC22A12CCR4EPAS1PTGES2MAPT
SCHEMBL5528618 0.82 L3MBTL1 (0.46) SLC22A12CCR4ALDH1A1MAPTL3MBTL1
SCHEMBL646910 0.81 TRPV4 (0.47) SLC22A12EPAS1PTGES2MAPT
SCHEMBL163836 0.81 ALDH1A1 (0.48) SLC22A12EPAS1ALDH1A1VEGFA
SCHEMBL29572365 0.81 ALDH1A1 (0.48) SLC22A12EPAS1ALDH1A1VEGFA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 608 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108658816-B N-aryl amidine substituted trifluoroethyl sulfide derivatives useful as acaricides and insecticides 拜尔农作物科学股份公司 2023-05-02 CN claimed
EP-3010893-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2019-10-02 EP claimed
EP-3490379-A1 ACTIVE COMPOUND COMBINATIONS AND METHODS TO PROTECT THE PROPAGATION MATERIAL OF PLANTS Bayer CropScience Aktiengesellschaft (DE) 2019-06-05 EP claimed
CN-105722830-B Aryl thioethers derivative and aryl sulfoxid es derivative as acaricide and insecticide 拜耳作物科学股份公司 2019-06-04 CN claimed
US-20190159451-A1 ACTIVE COMPOUND COMBINATIONS AND METHODS TO PROTECT THE PROPAGATION MATERIAL OF PLANTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-05-30 US claimed
CN-109688816-A Active compound combinations and method for protecting plant propagation material 拜耳作物科学股份公司 2019-04-26 CN claimed
CN-105473558-B Aromatic yl sulfide derivative and aryl oxysulfide derivative as acaricide and insecticide 拜耳作物科学股份公司 2019-04-19 CN claimed
EP-3395171-A1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES Bayer CropScience Aktiengesellschaft (DE) 2018-10-31 EP claimed
EP-3010889-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-10-03 EP claimed
EP-2793578-B1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-06-06 EP claimed
WO-2012082542-A2 SOYBEAN EVENT SYHT04R AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF SYNGENTA PARTICIPATIONS AG (CH) 2012-06-21 WO claimed
WO-2012082548-A2 SOYBEAN EVENT SYHT0H2 AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF SYNGENTA PARTICIPATIONS AG (CH) 2012-06-21 WO claimed
WO-2012076471-A1 INSECTICIDAL MIXTURES WITH IMPROVED PROPERTIES BAYER CROPSCIENCE AG (DE) 2012-06-14 WO claimed
WO-2012045680-A2 INSECTICIDAL AND FUNGICIDAL ACTIVE SUBSTANCE COMBINATIONS BAYER CROPSCIENCE AG (DE) 2012-04-12 WO claimed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US claimed
WO-2011157778-A1 ACTIVE SUBSTANCE COMBINATIONS WITH INSECTICIDE AND ACARICIDE PROPERTIES BAYER CROPSCIENCE AG (DE) 2011-12-22 WO claimed
WO-2011029506-A1 3-[1-(3-HALOALKYL)-TRIAZOLYL]-PHENYL-SULFIDE DERIVATIVES FOR USE AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2011-03-17 WO claimed
US-20110045104-A1 3-[1-(3-Haloalkyl)triazolyl]phenyl sulphide derivatives as acaricides and insecticides BAYER CROPSCIENCE AG (DE) 2011-02-24 US claimed
US-20110046194-A1 3-Triazolylphenyl-substituted sulphide derivatives as acaricides and insecticides BAYER CROPSCIENCE AG (DE) 2011-02-24 US claimed
WO-2011020567-A1 3-TRIAZOLYLPHENYL-SUBSTITUTED SULFIDE DERIVATIVES FOR USE AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2011-02-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190159451-A1 ACTIVE COMPOUND COMBINATIONS AND METHODS TO PROTECT THE PROPAGATION MATERIAL OF PLANTS BROX, CAT, MPG SLC22A12 4829/4885CCR4 4021/4885EPAS1 4012/4885
US-20110045104-A1 3-[1-(3-Haloalkyl)triazolyl]phenyl sulphide derivatives as acaricides and insecticides ATL3, PDIA3, NAT1 SLC22A12 3099/4885CCR4 3043/4885EPAS1 3328/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 SLC22A12 3338/4885CCR4 4694/4885EPAS1 4201/4885
US-20110046194-A1 3-Triazolylphenyl-substituted sulphide derivatives as acaricides and insecticides CYP4B1, ARSA, C1S SLC22A12 3184/4885CCR4 2683/4885EPAS1 4435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.