SCHEMBL16848728

SCHEMBL16848728

Cc1c(F)c(F)c(OC(=O)C(C)C)c(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TAS1R3 Q7RTX0 9/20 0.40
▸ TAS1R1 Q7RTX1 9/20 0.40
▸ TAS1R2 Q8TE23 9/20 0.40
▸ ELANE P08246 2/20 0.38
▸ GAA P10253 2/20 0.35
▸ ALOX15 P16050 1/20 0.33
▸ LMNA P02545 1/20 0.32
▸ F10 P00742 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ TP53 P04637 1/20 0.31
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19105005 0.96 TAS1R3 (0.38) TAS1R3TAS1R1TAS1R2ELANEGAA
SCHEMBL26144738 0.92 ELANE (0.36) TAS1R3TAS1R1TAS1R2ELANEGAA
SCHEMBL26144727 0.90 ELANE (0.35) TAS1R3TAS1R1TAS1R2ELANEGAA
SCHEMBL11915792 0.89 ELANE (0.42) ELANEGAAALOX15
SCHEMBL12213944 0.77 MAPT (0.42) ELANEGAAALOX15MAPT
SCHEMBL23228270 0.76 FABP3 (0.35) ELANE
SCHEMBL26316856 0.76 ELANE (0.34) ELANE
SCHEMBL16838219 0.76 TAS1R3 (0.44) TAS1R3TAS1R1TAS1R2
SCHEMBL22381449 0.75 GAA (0.37) ELANEGAAALOX15F10
SCHEMBL19105004 0.75 ELANE (0.37) ELANEGAAALOX15L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12036078-B2 Oral products and methods for producing the same PolySpectra, Inc. (US) 2024-07-16 — — US disclosed
US-20230399515-A1 PHTHALOCYANINE DYE COMPOUNDS, CONJUGATES AND METHODS OF USE THEREOF Rakuten Medical, Inc. 2023-12-14 — — US disclosed
US-11802279-B2 Modified L-asparaginase JAZZ PHARMACEUTICALS IRELAND LTD. (IE) 2023-10-31 — — US disclosed
US-11788133-B2 Methods and compositions for sequencing complementary polynucleotides Singular Genomics Systems, Inc. (US) 2023-10-17 — — US disclosed
US-20230293701-A1 LIGAND COMPOUNDS, CONJUGATES, AND APPLICATIONS THEREOF ARGORNA PHARMACEUTICALS CO., LTD. (CN) 2023-09-21 — — US disclosed
US-11725077-B2 Olefin metathesis photopolymers PolySpectra, Inc. (US) 2023-08-15 — — US disclosed
US-20230250091-A1 ASGPR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES LYCIA THERAPEUTICS, INC. 2023-08-10 — — US disclosed
US-11697736-B2 Silicon containing detectable compounds Singular Genomics Systems, Inc. (US) 2023-07-11 — — US disclosed
US-20230193377-A1 METHODS AND COMPOSITIONS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES FIRST-CITIZENS BANK & TRUST COMPANY 2023-06-22 — — US disclosed
US-20230158155-A1 Cell Surface Receptor Binding Compounds and Conjugates LYCIA THERAPEUTICS, INC. 2023-05-25 — — US disclosed
US-20160121002-A1 Bioorthogonal Turn-on Probes THE GENERAL HOSPITAL CORPORATION (US) 2016-05-05 — — US disclosed
US-20150175998-A1 Methods and Kits to Create Protein Substrate˜HECT-Ubiquitin Ligase Pairs NORTHWESTERN UNIVERSITY 2015-06-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11697736-B2 Silicon containing detectable compounds AS3MT, SCLY, NASP TAS1R3 3183/4885TAS1R1 3315/4885TAS1R2 3642/4885
US-11802279-B2 Modified L-asparaginase DNPEP, LNPEP, ANPEP TAS1R3 4703/4885TAS1R1 4681/4885TAS1R2 4698/4885
US-20160121002-A1 Bioorthogonal Turn-on Probes MPI, TIPRL, BAZ1A TAS1R3 4086/4885TAS1R1 3298/4885TAS1R2 3803/4885
US-20230158155-A1 Cell Surface Receptor Binding Compounds and Conjugates M6PR, ASGR1, IGF2R TAS1R3 2981/4885TAS1R1 2921/4885TAS1R2 2835/4885
US-12036078-B2 Oral products and methods for producing the same CROCC, RPAP1, RUVBL1 TAS1R3 3710/4885TAS1R1 3637/4885TAS1R2 3588/4885
US-20230293701-A1 LIGAND COMPOUNDS, CONJUGATES, AND APPLICATIONS THEREOF ASGR1, HAVCR2, SLC10A1 TAS1R3 2609/4885TAS1R1 2512/4885TAS1R2 2407/4885
US-20230250091-A1 ASGPR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES ASGR1, LAMP2, FCGR2A TAS1R3 3208/4885TAS1R1 3231/4885TAS1R2 2742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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