Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28150211 | 0.93 | APP (0.53) | APPAKR1B1ALOX5MAPTALDH1A1 | |
| Formamide SCHEMBL15663241 | 0.79 | DPP4 (0.44) | ALDH1A1GABRA1GABRB2ADORA2AADORA1 | |
| Formamide SCHEMBL19272521 | 0.78 | TAAR1 (0.38) | MAPTPTPN5 | |
| SCHEMBL28149290 | 0.78 | APP (0.64) | APPALOX5MAPTGABRA1GABRB2 | |
| Formamide SCHEMBL12498232 | 0.73 | LOXL2 (0.39) | APPMAPTGAAADORA3ADORA2A | |
| SCHEMBL2866344 | 0.71 | ANPEP (0.48) | MAPTALDH1A1GAAPKMGABRA1 | |
| SCHEMBL4434804 | 0.71 | BAZ2B (0.47) | — | |
| SCHEMBL4444938 | 0.70 | MKNK1 (0.49) | MAPTUSP7 | |
| SCHEMBL4529434 | 0.70 | GABRA1 (0.50) | GABRA1GABRB2ANPEPDPP4 | |
| SCHEMBL983104 | 0.70 | GABRA1 (0.48) | AKR1B1ALDH1A1GABRA1GABRB2PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218124-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | ORION CORPORATION (FI) | 2015-08-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218124-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | COMT, PNMT, HNMT | APP 3851/4885AKR1B1 226/4885ALOX5 2132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.