SCHEMBL170252

SCHEMBL170252

COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 20/20 1.00
PTGS1 P23219 3/20 1.00
ALOX5 P09917 1/20 0.88
LTC4S Q16873 1/20 0.88
CYP3A4 P08684 2/20 0.81
CYP2C9 P11712 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5530903 0.95 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4SCYP3A4
SCHEMBL170010 0.94 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4S
Fiboflapon SCHEMBL29379276 0.94 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4SCYP3A4
Fiboflapon SCHEMBL11820 0.94 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4SCYP3A4
SCHEMBL1722524 0.94 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4S
Fiboflapon SCHEMBL29723363 0.94 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4SCYP3A4
Fiboflapon SCHEMBL29504643 0.93 ALOX5AP (0.99) ALOX5APPTGS1ALOX5LTC4SCYP3A4
Fiboflapon SCHEMBL1254873 0.93 ALOX5AP (0.99) ALOX5APPTGS1ALOX5LTC4SCYP3A4
Fiboflapon SCHEMBL28358195 0.93 ALOX5AP (0.99) ALOX5APPTGS1ALOX5LTC4SCYP3A4
SCHEMBL5530433 0.93 ALOX5AP (1.00) ALOX5APPTGS1ALOX5LTC4S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200147064-A1 Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor AUTOIMMUNE PHARMA LLC (US) 2020-05-14 US claimed
US-20120232031-A1 INJECTABLE FORMULATIONS FOR INTRA-ARTICULAR OR PERI-ARTICULAR ADMINISTRATION PANMIRA PHARMACEUTICALS, LLC (US) 2012-09-13 US claimed
EP-1943219-B8 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS PANMIRA PHARMACEUTICALS LLC (US) 2012-03-07 EP claimed
US-20120027842-A1 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE AMIRA PHARMACEUTICALS, INC. (US) 2012-02-02 US claimed
EP-2404904-A1 5-lipoxygenase-activating protein (FLAP) inhibitors Amira Pharmaceuticals, Inc. (US) 2012-01-11 EP claimed
US-20110311613-A1 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS AMIRA PHARMACEUTICAL, INC. (US) 2011-12-22 US claimed
EP-2381945-A2 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS Amira Pharmaceuticals, Inc. (US) 2011-11-02 EP claimed
US-7977359-B2 5-lipdxygenase-activating protein (FLAP) inhibitors AMIRA PHARMACEUTICALS, INC. (US) 2011-07-12 US claimed
JP-4705986-B2 2011-06-22 JP claimed
WO-2010075314-A2 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS AMIRA PHARMACEUTICALS, INC. (US) 2010-07-01 WO claimed
US-20090192171-A1 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors AMIRA PHARMACEUTICALS, INC. (US) 2009-07-30 US claimed
EP-1943219-A2 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS Amira Pharmaceuticals, Inc. (US) 2008-07-16 EP claimed
US-20070219206-A1 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-09-20 US claimed
WO-2007056021-A2 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-05-18 WO claimed
US-20070105866-A1 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-05-10 US claimed
US-20200147064-A1 Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor AUTOIMMUNE PHARMA LLC (US) 2020-05-14 US disclosed
WO-2018152405-A1 REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR AUTOIMMUNE PHARMA LLC (US) 2018-08-23 WO disclosed
WO-2007056220-A2 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-05-18 WO disclosed
WO-2007056021-A2 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-05-18 WO disclosed
US-20070105866-A1 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS AMIRA PHARMACEUTICALS, INC. (US) 2007-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070105866-A1 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS ALOX5, ALOX15B, ALOX15 ALOX5AP 4/4885PTGS1 27/4885ALOX5 1/4885
US-20200147064-A1 Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor LTB4R, LTC4S, LTB4R2 ALOX5AP 35/4885PTGS1 22/4885ALOX5 7/4885
US-20090192171-A1 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors ALOX5, ALOX15B, ALOX15 ALOX5AP 4/4885PTGS1 27/4885ALOX5 1/4885
US-20120027842-A1 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE FEN1, SERPINB1, EYA2 ALOX5AP 100/4885PTGS1 264/4885ALOX5 69/4885
US-20070219206-A1 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS ALOX5, ALOX15B, ALOX15 ALOX5AP 4/4885PTGS1 27/4885ALOX5 1/4885
US-20110311613-A1 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS TSLP, SUCLG1, SERPINB1 ALOX5AP 96/4885PTGS1 495/4885ALOX5 70/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.