SCHEMBL17047756

SCHEMBL17047756

CC1=C(C)C(Cl)N(c2ccccc2)C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.39
MEN1 O00255 3/20 0.39
MAPK1 P28482 2/20 0.38
GAA P10253 4/20 0.37
POLB P06746 2/20 0.37
RAB9A P51151 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
MAPT P10636 2/20 0.36
BCHE P06276 1/20 0.36
PTGS2 P35354 1/20 0.36
LOX P28300 1/20 0.36
LOXL3 P58215 1/20 0.36
LOXL4 Q96JB6 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.36
KAT2B Q92831 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17047781 0.90 FAAH (0.41) KMT2AMEN1SMN1; SMN2
SCHEMBL17047692 0.79 RAB9A (0.42) KMT2AMEN1MAPK1GAAPOLB
SCHEMBL17047742 0.76 MEN1 (0.54) KMT2AMEN1GAAPOLBSMN1; SMN2
SCHEMBL17047757 0.72 HPGD (0.43) KMT2AMEN1MAPK1GAARAB9A
SCHEMBL17047731 0.72 GAA (0.36) KMT2AMEN1MAPK1GAAPOLB
SCHEMBL22984389 0.67 LMNA (0.47) KMT2AMEN1MAPK1GAARAB9A
SCHEMBL11206667 0.67 HSD11B1 (0.41) KMT2AMEN1GAAPOLBSMN1; SMN2
SCHEMBL20707982 0.67 GAA (0.38) KMT2AMEN1MAPK1GAAPOLB
3,4-Dimethylphenylmaleimide SCHEMBL5074358 0.66 PARP1 (0.53) MAPK1GAASMN1; SMN2MAPTBCHE
SCHEMBL6713101 0.66 MAOA (0.48) KMT2AMEN1GAAPOLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3110808-B1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-29 EP disclosed
US-20180220650-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-09 US disclosed
US-20180220650-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-09 US disclosed
US-20180220650-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-09 US disclosed
EP-3331875-A1 PLANT GROWTH REGULATOR COMPOUNDS Syngenta Participations AG (CH) 2018-06-13 EP disclosed
US-9751867-B2 Plant growth regulating compounds SYNGENTA PARTICIPATIONS AG (CH) 2017-09-05 US disclosed
US-9751867-B2 Plant growth regulating compounds SYNGENTA PARTICIPATIONS AG (CH) 2017-09-05 US disclosed
US-9751867-B2 Plant growth regulating compounds SYNGENTA PARTICIPATIONS AG (CH) 2017-09-05 US disclosed
WO-2017025427-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2017-02-16 WO disclosed
WO-2017025427-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2017-02-16 WO disclosed
EP-3110808-A1 PLANT GROWTH REGULATING COMPOUNDS Syngenta Participations AG (CH) 2017-01-04 EP disclosed
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-12-22 US disclosed
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-12-22 US disclosed
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-12-22 US disclosed
WO-2015128321-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2015-09-03 WO disclosed
WO-2015128321-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2015-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS GHDC, GAK, EIF4G2 KMT2A 3798/4885MEN1 4325/4885MAPK1 520/4885
US-20180220650-A1 PLANT GROWTH REGULATOR COMPOUNDS GHITM, GHDC, SGTA KMT2A 3306/4885MEN1 3800/4885MAPK1 781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.