Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 14/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 11/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708225 | 0.89 | KLKB1 (0.35) | CD274PDCD1NTRK1EZH2RAB9A | |
| SCHEMBL1708584 | 0.84 | CD274 (0.41) | CD274PDCD1NTRK1EEDSUZ12 | |
| SCHEMBL1707949 | 0.81 | PDCD1 (0.36) | CD274PDCD1RAB9A | |
| SCHEMBL1707867 | 0.79 | ALDH1A1 (0.40) | CD274PDCD1RAB9AMEN1KMT2A | |
| SCHEMBL1708201 | 0.78 | PDCD1 (0.33) | CD274PDCD1KMT2A | |
| SCHEMBL1707845 | 0.78 | PDCD1 (0.33) | CD274PDCD1KMT2A | |
| SCHEMBL1708583 | 0.77 | FFAR1 (0.49) | CD274PDCD1 | |
| SCHEMBL13048415 | 0.77 | FFAR1 (0.42) | CD274PDCD1NTRK1EEDSUZ12 | |
| SCHEMBL1708437 | 0.77 | PDCD1 (0.33) | CD274PDCD1 | |
| SCHEMBL1708101 | 0.76 | RORC (0.33) | CD274PDCD1EEDSUZ12EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |