Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707949 | 0.91 | PDCD1 (0.36) | HAO1POLBINSRIGF1RPDCD1 | |
| SCHEMBL1707964 | 0.84 | INSR (0.36) | HAO1INSRIGF1RS1PR4S1PR5 | |
| SCHEMBL1707867 | 0.77 | ALDH1A1 (0.40) | HAO1POLBINSRIGF1RPDCD1 | |
| SCHEMBL1708332 | 0.77 | ALDH1A1 (0.32) | HAO1POLBINSRIGF1RPDCD1 | |
| SCHEMBL1708437 | 0.77 | PDCD1 (0.33) | HAO1PDCD1CD274 | |
| SCHEMBL1708634 | 0.76 | TP53 (0.35) | — | |
| SCHEMBL10291784 | 0.76 | FFAR1 (0.39) | FFAR1 | |
| SCHEMBL1707963 | 0.75 | FFAR1 (0.45) | FFAR1 | |
| SCHEMBL1707908 | 0.75 | CD274 (0.41) | PDCD1CD274 | |
| SCHEMBL1708101 | 0.73 | RORC (0.33) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |