Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110187 | 0.88 | TRPV4 (0.38) | TRPV4MGLLDRD2DRD4DRD3 | |
| SCHEMBL31433034 | 0.84 | MGLL (0.38) | TRPV4MGLLDRD2DRD4DRD3 | |
| SCHEMBL17110424 | 0.84 | PRMT1 (0.37) | TRPV4 | |
| SCHEMBL17110205 | 0.79 | LRRK2 (0.34) | TRPV4AURKACDK1AURKB | |
| SCHEMBL16654536 | 0.77 | SPR (0.38) | TRPV4 | |
| SCHEMBL17110178 | 0.77 | PLAT (0.40) | DRD2DRD4DRD3 | |
| SCHEMBL17110206 | 0.76 | LMNA (0.40) | — | |
| SCHEMBL17110464 | 0.74 | SPR (0.33) | TRPV4MGLL | |
| SCHEMBL17110204 | 0.73 | ALDH1A1 (0.37) | TRPV4 | |
| SCHEMBL17110207 | 0.73 | LMNA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365522-B2 | Pyrazole amide derivative | AMGEN INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150266824-A1 | Pyrazole Amide Derivative | TEIJIN LIMITED (JP) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266824-A1 | Pyrazole Amide Derivative | RORC, RORB, RORA | TRPV4 1692/4885MGLL 4455/4885DRD2 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.