Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110187 | 0.85 | TRPV4 (0.38) | KEAP1NFE2L2HSD11B1KDM4CKDM5A | |
| SCHEMBL17048835 | 0.83 | PRMT1 (0.36) | POLBHSD11B1NR3C1KDM4ETDP1 | |
| SCHEMBL17048838 | 0.83 | PRMT1 (0.36) | POLBHSD11B1NR3C1KDM4ETDP1 | |
| SCHEMBL17110206 | 0.83 | LMNA (0.40) | KDM4EALDH1A1 | |
| SCHEMBL1406946 | 0.83 | KEAP1 (0.40) | LRRK2KEAP1NFE2L2HSD11B1NR3C1 | |
| SCHEMBL17110204 | 0.81 | ALDH1A1 (0.37) | KEAP1NFE2L2HSD11B1KDM4CKDM5A | |
| SCHEMBL1407026 | 0.80 | CNR2 (0.39) | KEAP1NFE2L2HSD11B1CNR2KDM4C | |
| SCHEMBL1407004 | 0.80 | HCAR3 (0.38) | KEAP1NFE2L2HSD11B1CNR2KDM4C | |
| SCHEMBL17110193 | 0.80 | HSD11B1 (0.40) | LRRK2KEAP1NFE2L2HSD11B1NR3C1 | |
| SCHEMBL17110437 | 0.79 | TRPV4 (0.38) | TRPV4AURKACDK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365522-B2 | Pyrazole amide derivative | AMGEN INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150266824-A1 | Pyrazole Amide Derivative | TEIJIN LIMITED (JP) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266824-A1 | Pyrazole Amide Derivative | RORC, RORB, RORA | LRRK2 3254/4885POLB 4102/4885KEAP1 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.