Sugi Predict

Sugi Predict / Compounds / SCHEMBL1723229

SCHEMBL1723229

SCHEMBL1723229

CN(C)Cc1cccc(B(O)O)c1

nearest known ligand 0.60

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ENPP2 Q13822 7/20 0.60
▸ LPL P06858 2/20 0.54
▸ LIPG Q9Y5X9 2/20 0.54
▸ NOS1 P29475 1/20 0.49
▸ ALDH1A1 P00352 2/20 0.48
▸ TSHR P16473 1/20 0.48
▸ KDM4E B2RXH2 1/20 0.44
▸ CXCR1 P25024 2/20 0.43
▸ CXCR2 P25025 2/20 0.43
▸ MGLL Q99685 2/20 0.42
▸ HTR7 P34969 1/20 0.41
▸ CHRNB2 P17787 1/20 0.40
▸ CHRNA4 P43681 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19492821 0.85 ENPP2 (0.56) ENPP2LPLLIPGALDH1A1KDM4E
SCHEMBL6353060 0.84 ENPP2 (0.55) ENPP2LPLLIPGALDH1A1TSHR
SCHEMBL17359804 0.82 ENPP2 (0.53) ENPP2LPLLIPGALDH1A1KDM4E
SCHEMBL28413768 0.80 ENPP2 (0.55) ENPP2LPLLIPGALDH1A1TSHR
SCHEMBL2634549 0.80 ENPP2 (0.50) ENPP2LPLLIPGTSHRCXCR1
SCHEMBL989636 0.79 ALDH1A1 (0.67) NOS1ALDH1A1TSHRHTR7CHRNB2
SCHEMBL29953749 0.79 ENPP2 (0.49) ENPP2LPLLIPGALDH1A1KDM4E
SCHEMBL692342 0.78 ENPP2 (0.67) ENPP2LPLLIPGALDH1A1KDM4E
SCHEMBL723106 0.78 ENPP2 (0.67) ENPP2LPLLIPGALDH1A1TSHR
SCHEMBL29950926 0.78 ENPP2 (0.51) ENPP2LPLLIPGALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103459-A1 SUBSTITUTED AZACYLES AS TRPM8 MODULATORS GIVAUDAN SA (CH) 2026-04-16 — — US disclosed
US-12528801-B2 Substituted azacyles as TRPM8 modulators GIVAUDAN SA (CH) 2026-01-20 — — US disclosed
CN-114555594-B Substituted azacycles as TRMP modulators 奇华顿股份有限公司 2025-03-18 — — CN disclosed
CN-113637005-B KRAS inhibitors for cancer treatment 泰励生物科技（上海）有限公司 2024-05-24 — — CN disclosed
US-20240132487-A1 SUBSTITUTED AZACYLES AS TRMP8 MODULATORS GIVAUDAN SA (CH) 2024-04-25 — — US disclosed
US-20240025858-A1 CANNABINOID DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHOD OF PREPARATION THEREOF JAZZ PHARMACEUTICALS RESEARCH UK LIMITED (GB) 2024-01-25 — — US disclosed
US-20240025858-A1 CANNABINOID DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHOD OF PREPARATION THEREOF JAZZ PHARMACEUTICALS RESEARCH UK LIMITED (GB) 2024-01-25 — — US disclosed
US-20230406849-A1 KRAS INHIBITORS FOR TREATMENT OF CANCERS TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED (CN) 2023-12-21 — — US disclosed
US-20230322689-A1 IONIZABLE LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS SunVax mRNA Therapeutics Inc. (US) 2023-10-12 — — US disclosed
US-20230322689-A1 IONIZABLE LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS SunVax mRNA Therapeutics Inc. (US) 2023-10-12 — — US disclosed
US-8314112-B2 Pyrrolopyrimidines and pyrrolopyridines NOVARTIS AG (CH) 2012-11-20 — — US disclosed
EP-2403833-A1 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS Sirtris Pharmaceuticals, Inc. (US) 2012-01-11 — — EP disclosed
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors UCB PHARMA S.A. (BE) 2010-12-02 — — US disclosed
EP-2242756-A2 PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES Novartis AG (CH) 2010-10-27 — — EP disclosed
WO-2010101949-A1 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS SIRTRIS PHARMACEUTICALS, INC. (US) 2010-09-10 — — WO disclosed
US-20090181941-A1 Pyrrolopyrimidines and Pyrrolopyridines NOVARTIS AG (CH) 2009-07-16 — — US disclosed
WO-2009087225-A2 PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES NOVARTIS AG (CH) 2009-07-16 — — WO disclosed
EP-2029570-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB Pharma S.A. (BE) 2009-03-04 — — EP disclosed
WO-2007141504-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2007-12-13 — — WO disclosed
US-20070232615-A1 Chemical Compounds SMITHKLINE BEECHAM CORPORATION 2007-10-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260103459-A1 SUBSTITUTED AZACYLES AS TRPM8 MODULATORS TRPM8, TRPM7, TRPM5 ENPP2 4310/4885LPL 2835/4885LIPG 2646/4885
US-20230406849-A1 KRAS INHIBITORS FOR TREATMENT OF CANCERS KRAS, NRAS, HRAS ENPP2 2874/4885LPL 4637/4885LIPG 3224/4885
US-20240132487-A1 SUBSTITUTED AZACYLES AS TRMP8 MODULATORS TRPM8, TRPM7, TRPM5 ENPP2 2522/4885LPL 3459/4885LIPG 2199/4885
US-12528801-B2 Substituted azacyles as TRPM8 modulators TRPM8, TRPM7, TRPM4 ENPP2 4166/4885LPL 2903/4885LIPG 3062/4885
US-20070232615-A1 Chemical Compounds CXCR4, CCR5, CXCR3 ENPP2 251/4885LPL 4540/4885LIPG 1228/4885
US-20090181941-A1 Pyrrolopyrimidines and Pyrrolopyridines ALK, ACVR1, PTPN4 ENPP2 366/4885LPL 2217/4885LIPG 2295/4885
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors PIKFYVE, PI4KA, PIK3CA ENPP2 1278/4885LPL 2801/4885LIPG 787/4885
US-20240025858-A1 CANNABINOID DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHOD OF PREPARATION THEREOF CNR1, CNR2, FAAH ENPP2 923/4885LPL 2791/4885LIPG 2588/4885
US-20230322689-A1 IONIZABLE LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS PHOSPHO1, SGMS1, PLIN3 ENPP2 1683/4885LPL 169/4885LIPG 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.