SCHEMBL17278688

SCHEMBL17278688

CC1(C)c2ccccc2N(c2cc(-c3nc(-c4ccccc4)nc(-c4ccc(-c5ccccc5)cc4)n3)cc(N3c4ccccc4Sc4ccccc43)c2)c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADAMTS5 Q9UNA0 3/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.34
▸ BCHE P06276 3/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.32
▸ MAOA P21397 1/20 0.32
▸ MARK4 Q96L34 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ LMNA P02545 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ NOX1 Q9Y5S8 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ ITGB2 P05107 1/20 0.31
▸ ICAM1 P05362 1/20 0.31
▸ ITGAL P20701 1/20 0.31
▸ ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17278693 1.00 ADAMTS5 (0.34) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278681 0.98 ADAMTS5 (0.36) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278696 0.93 MEN1 (0.35) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278700 0.92 MEN1 (0.37) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278675 0.92 HDAC6 (0.41) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278601 0.92 L3MBTL1 (0.38) ADAMTS5L3MBTL1MAPTLMNAMAPK1
SCHEMBL17278602 0.92 L3MBTL1 (0.38) ADAMTS5L3MBTL1MAPTLMNAMAPK1
SCHEMBL17278692 0.91 ADAMTS5 (0.34) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278671 0.90 HDAC6 (0.42) ADAMTS5HDAC6BCHEL3MBTL1MAOA
SCHEMBL17278698 0.90 MEN1 (0.36) ADAMTS5HDAC6MAOAMARK4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11730052-B2 Light-emitting device IDEMITSU KOSAN CO., LTD. (JP) 2023-08-15 — — US disclosed
US-11730052-B2 Light-emitting device IDEMITSU KOSAN CO., LTD. (JP) 2023-08-15 — — US disclosed
US-20190109285-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2019-04-11 — — US disclosed
US-10186665-B2 Organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2019-01-22 — — US disclosed
US-9882144-B2 Organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2018-01-30 — — US disclosed
US-9882144-B2 Organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2018-01-30 — — US disclosed
US-20160197287-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2016-07-07 — — US disclosed
US-20160197287-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2016-07-07 — — US disclosed
US-20160028025-A1 LIGHT-EMITTING DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2016-01-28 — — US disclosed
US-20160028025-A1 LIGHT-EMITTING DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2016-01-28 — — US disclosed
US-20150340623-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2015-11-26 — — US disclosed
US-20150340623-A1 ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2015-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190109285-A1 ORGANIC ELECTROLUMINESCENT ELEMENT TCF4, TRPA1, EML4 ADAMTS5 4577/4885HDAC6 3505/4885BCHE 3217/4885
US-11730052-B2 Light-emitting device GRK7, GRK1, CTNND1 ADAMTS5 4860/4885HDAC6 4858/4885BCHE 4117/4885
US-10186665-B2 Organic electroluminescent element TCF4, TRPA1, EML4 ADAMTS5 4577/4885HDAC6 3505/4885BCHE 3217/4885
US-20160197287-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AOC2, AZI2, RER1 ADAMTS5 4864/4885HDAC6 3806/4885BCHE 3175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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